Distribution and antigenicity of fibronectin binding proteins (SfbI and SfbII) of Streptococcus pyogenes clinical isolates from the Northern Territory, Australia

Fibronectin binding proteins play an important role in the adherence and invasion of group A streptococci (GAS). Genotypically distinct GAS isolates were screened for the presence and expression of two streptococcal fibronectin binding protein genes, sfbI and sfbII. Of the tested strains, 64 and 36%...

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Bibliographic Details
Published in:Journal of clinical microbiology 2000, Vol.38 (1), p.389-392
Main Authors: GOODFELLOW, A. M, HIBBLE, M, TALAY, S. R, KREIKEMEYER, B, CURRIE, B. J, SRIPRAKASH, K. S, CHHATWAL, G. S
Format: Article
Language:English
Subjects:
Adhesins, Bacterial
Adolescent
Adult
Antibodies, Bacterial - blood
Antigens, Bacterial - immunology
Bacterial Adhesion
Bacterial Proteins - immunology
Bacteriology
Biological and medical sciences
Carrier Proteins - immunology
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
fibronectin-binding protein
Fibronectins
Fundamental and applied biological sciences. Psychology
Humans
Immunoglobulin G - immunology
Membrane Proteins - immunology
Microbiology
Middle Aged
Northern Territory
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
sfbI gene
SfbI protein
sfbII gene
SfbII protein
Streptococcal Infections - blood
Streptococcus pyogenes
Streptococcus pyogenes - immunology
Streptococcus pyogenes - pathogenicity
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Summary:Fibronectin binding proteins play an important role in the adherence and invasion of group A streptococci (GAS). Genotypically distinct GAS isolates were screened for the presence and expression of two streptococcal fibronectin binding protein genes, sfbI and sfbII. Of the tested strains, 64 and 36% were shown to harbor and express the sfbI and sfbII genes, respectively. All sfbII-positive strains tested were also positive for sfbI, but only 28% of the sfbII-negative strains were positive for sfbI. High levels of immunoglobulin G antibodies to both SfbI and SfbII were found in sera from 80 subjects with defined streptococcal infections.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.38.1.389-392.2000