Low-Density Lipoprotein Cholesterol Is a Possible Blood Biomarker of Schizoid Personality Traits among Females

Lower serum levels of low-density lipoprotein cholesterol (LDL-C) have been suggested to indicate higher suicide risk and various psychiatric symptoms. Previously, we reported that lower serum LDL-C levels are associated with loneliness, social phobia, isolated life with little social support, and l...

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Bibliographic Details
Published in:Journal of personalized medicine 2022-01, Vol.12 (2), p.131
Main Authors: Hayakawa, Kohei, Watabe, Motoki, Horikawa, Hideki, Sato-Kasai, Mina, Shimokawa, Norihiro, Nakao, Tomohiro, Kato, Takahiro A
Format: Article
Language:English
Subjects:
Anxiety
Biomarkers
Cholesterol
Decision making
Fear & phobias
Females
Loneliness
Low density lipoprotein
Mental depression
Mental disorders
Patients
Personality
Personality traits
Precision medicine
Schizophrenia
Serum levels
Social interactions
Social support
Suicide
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Summary:Lower serum levels of low-density lipoprotein cholesterol (LDL-C) have been suggested to indicate higher suicide risk and various psychiatric symptoms. Previously, we reported that lower serum LDL-C levels are associated with loneliness, social phobia, isolated life with little social support, and lower trust in others among young non-clinical females. Thus, we hypothesize that schizoid personality traits may be associated with lower serum LDL-C. We here verified this hypothesis using non-clinical data and clinical data with schizophrenia. Using the database from the Midlife in Japan (MIDJA), a cohort of residents living in Tokyo, we analyzed whether schizoid-related interpersonal characteristics were associated with LDL-C. In addition, we assessed the association between blood biomarkers including LDL-C and schizoid personality traits in 101 adult non-clinical volunteers. Finally, we evaluated the interaction between LDL-C and social decision making of patients with schizophrenia. In female non-clinical volunteers, serum LDL-C level was a predictive factor and negatively correlated with schizoid personality traits. Female patients with schizophrenia, whose serum LDL-C levels were lower, tended not to trust other females. The present findings suggest that LDL-C may influence schizoid personality traits in females, which provide a basis for further investigation into the biological aspects of schizoid personality disorder.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm12020131