Serum Levels of MMP-8 and MMP-9 as Markers in Chronic Subdural Hematoma

Chronic subdural hematoma (CSDH) is a common neurological disease that involves the collection of blood products in the subdural space. The progression of CSDH is an angiogenic and inflammatory process, but the multifactorial mechanisms underlying CSDH are still not fully understood. We aimed to ide...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical medicine 2022-02, Vol.11 (4), p.902
Main Authors: Su, Gao-Jian, Gao, Jie, Wu, Chu-Wei, Zou, Jun-Feng, Zhang, Di, Zhu, Dong-Liang, Liu, Jun, Zhang, Jie-Hua, Huang, Xian-Jian
Format: Article
Language:English
Subjects:
Angiogenesis
Biomarkers
Blood vessels
Clinical medicine
Cytokines
Disease
Epidermal growth factor
Gene expression
Hematoma
Inflammation
Pathogenesis
Patients
Software
Surgery
Tumor necrosis factor-TNF
Vascular endothelial growth factor
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chronic subdural hematoma (CSDH) is a common neurological disease that involves the collection of blood products in the subdural space. The progression of CSDH is an angiogenic and inflammatory process, but the multifactorial mechanisms underlying CSDH are still not fully understood. We aimed to identify one or more factors that may play an important role in the development of CSDH. We enrolled 83 patients with CSDH, including 17 postoperative patients, and analyzed 20 markers in the hematoma fluid and peripheral blood of each patient. Overall differential gene expression was examined to identify the representative markers. The concentration of MMP-8 was significantly lower in the postoperative group than in the preoperative group. The concentration of MMP-9 was significantly higher in the postoperative group than in the preoperative group. These findings indicate that MMP-8 and MMP-9 may play important roles in the pathophysiology of CSDH. Understanding the pathways associated with CSDH may provide insights for improving disease outcomes.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11040902