Selective Forms of Therapy in the Treatment of Inflammatory Bowel Diseases

Selective interference with the functioning of the immune system consisting of the selective blockade of pro-inflammatory factors is a modern, promising, and developing strategy for the treatment of diseases resulting from dysregulation of the immune system, including inflammatory bowel disease. Inh...

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Bibliographic Details
Published in:Journal of clinical medicine 2022-02, Vol.11 (4), p.994
Main Authors: Kofla-Dłubacz, Anna, Akutko, Katarzyna, Krzesiek, Elżbieta, Jamer, Tatiana, Braksator, Joanna, Grębska, Paula, Pytrus, Tomasz, Stawarski, Andrzej
Format: Article
Language:English
Subjects:
Biological products
Bowel disease
Clinical medicine
Clinical trials
Crohn's disease
Cytokines
Drug dosages
Immune system
Lymphocytes
Monoclonal antibodies
Remission (Medicine)
Review
Tumor necrosis factor-TNF
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Summary:Selective interference with the functioning of the immune system consisting of the selective blockade of pro-inflammatory factors is a modern, promising, and developing strategy for the treatment of diseases resulting from dysregulation of the immune system, including inflammatory bowel disease. Inhibition of the TNF alpha pathway, group 12/23 cytokines, and lymphocyte migration is used in the treatment of severe or moderate ulcerative colitis and Crohn's disease. Intracellular signal transduction by influencing the phosphorylation of SAT (signal transducer and activator of transcription) proteins remains in clinical trials.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11040994