Retrospective Analysis of Patients with Gynaecological Uterine Sarcomas in a Tertiary Hospital

Uterine sarcomas are rare and heterogeneous malignancies accounting for 1% to 3% of all gynaecological tumours. There are many histological subtypes recognised, including leiomyosarcomas, endometrial stromal sarcoma, and uterine carcinosarcoma, although the latest has been recently discarded in this...

Full description

Saved in:
Bibliographic Details
Published in:Journal of personalized medicine 2022-02, Vol.12 (2), p.222
Main Authors: Ruiz-Minaya, Maria, Mendizabal-Vicente, Elsa, Vasquez-Jimenez, Wenceslao, Perez-Burrel, Laura, Aracil-Moreno, Irene, Agra-Pujol, Carolina, Bernal-Claverol, Mireia, Martínez-Bernal, Beatriz L, Muñoz-Fernández, Mercedes, Morote-Gonzalez, Melanie, Ortega, Miguel A, Lizarraga-Bonelli, Santiago, De Leon-Luis, Juan A
Format: Article
Language:English
Subjects:
Age
Chemotherapy
Comparative analysis
Endometrium
Gynecology
Medical prognosis
Metastasis
Patients
Precision medicine
Prognosis
Radiation therapy
Sarcoma
Statistical analysis
Surgery
Systematic review
Tumors
Uterine cancer
Uterus
Variables
Variance analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Uterine sarcomas are rare and heterogeneous malignancies accounting for 1% to 3% of all gynaecological tumours. There are many histological subtypes recognised, including leiomyosarcomas, endometrial stromal sarcoma, and uterine carcinosarcoma, although the latest has been recently discarded in this group. Despite its low incidence, these types of cancer currently entail multiple challenges, either in diagnostics or clinical management, with a poor prognosis associated. The present work aimed to complete a comparative analysis of the different histological subtypes based on the clinicopathological characteristics of our population, the therapeutic characteristics, and associated prognosis in 161 patients treated in our centre during the period between 1985 and 2020. Moreover, a systematic review grouped a total of 2211 patients with a diagnosis of uterine sarcoma from 19 articles published in 16 countries from 2002 to 2021 was performed, all with retrospective analyses. Our results showed that apart from uterine carcinosarcoma, leiomyosarcoma is the most frequent subtype of uterine sarcoma, with unique clinical, demographic, and survival parameters. To our knowledge, this is the first systematic review conducted in this field and, thus, it shows the difficulties of collecting a significant number of patients per year, a valid reason why multicentre or national registries are recommended to allow a more exhaustive analysis of this pathology.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm12020222