Association of Circulating Proteins with Death or Lung Transplant in Patients with Idiopathic Pulmonary Fibrosis in the IPF-PRO Registry Cohort

Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease with a variable clinical course. Biomarkers that predict patient outcomes are needed. We leveraged data from 300 patients in the multicenter IPF-PRO Registry to determine associations between circulating proteins and t...

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Bibliographic Details
Published in:Lung 2022-02, Vol.200 (1), p.11-18
Main Authors: Todd, Jamie L., Neely, Megan L., Overton, Robert, Mulder, Hillary, Roman, Jesse, Lasky, Joseph A., de Andrade, Joao A., Gulati, Mridu, Huang, Howard, Leonard, Thomas B., Hesslinger, Christian, Noth, Imre, Belperio, John A., Flaherty, Kevin R., Palmer, Scott M.
Format: Article
Language:English
Subjects:
Analysis
Aptamers
Biomarkers
Care and treatment
Cohort Studies
Death
Fibrosis
Humans
Idiopathic Pulmonary Fibrosis
Lung diseases
Lung Transplantation
Lung transplants
Lungs
Medical colleges
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Mortality
Observational studies
Patients
Pharmaceutical industry
Pneumology/Respiratory System
Prognosis
Proteins
Proteomics
Pulmonary fibrosis
Registries
Transplantation of organs, tissues, etc
Transplants
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Summary:Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease with a variable clinical course. Biomarkers that predict patient outcomes are needed. We leveraged data from 300 patients in the multicenter IPF-PRO Registry to determine associations between circulating proteins and the composite outcome of respiratory death or lung transplant. Plasma collected at enrollment was analyzed using aptamer-based proteomics (1305 proteins). Over a median follow-up of 30.4 months, there were 76 respiratory deaths and 26 lung transplants. In unadjusted univariable analyses, 61 proteins were significantly associated with the outcome (hazard ratio > 2 or 
ISSN:0341-2040
1432-1750
DOI:10.1007/s00408-021-00505-y