Formation and repair of unavoidable, endogenous interstrand cross-links in cellular DNA

Genome integrity is essential for life and, as a result, DNA repair systems evolved to remove unavoidable DNA lesions from cellular DNA. Many forms of life possess the capacity to remove interstrand DNA cross-links (ICLs) from their genome but the identity of the naturally-occurring, endogenous subs...

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Bibliographic Details
Published in:DNA repair 2021-02, Vol.98, p.103029-103029, Article 103029
Main Authors: Housh, Kurt, Jha, Jay S., Haldar, Tuhin, Amin, Saosan Binth Md, Islam, Tanhaul, Wallace, Amanda, Gomina, Anuoluwapo, Guo, Xu, Nel, Christopher, Wyatt, Jesse W., Gates, Kent S.
Format: Article
Language:English
Subjects:
Animals
DNA Adducts - metabolism
DNA damage
DNA Repair
Endogenous DNA damage
Humans
ICL
Interstrand cross-links
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Summary:Genome integrity is essential for life and, as a result, DNA repair systems evolved to remove unavoidable DNA lesions from cellular DNA. Many forms of life possess the capacity to remove interstrand DNA cross-links (ICLs) from their genome but the identity of the naturally-occurring, endogenous substrates that drove the evolution and retention of these DNA repair systems across a wide range of life forms remains uncertain. In this review, we describe more than a dozen chemical processes by which endogenous ICLs plausibly can be introduced into cellular DNA. The majority involve DNA degradation processes that introduce aldehyde residues into the double helix or reactions of DNA with endogenous low molecular weight aldehyde metabolites. A smaller number of the cross-linking processes involve reactions of DNA radicals generated by oxidation.
ISSN:1568-7864
1568-7856
1568-7856
DOI:10.1016/j.dnarep.2020.103029