In vitro activity of the antimicrobial peptides h-Lf1-11, MSI-78, LL-37, fengycin 2B, and magainin-2 against clinically important bacteria

We investigated the antibacterial activity of the antimicrobial peptides h-Lf1-11, MSI-78, LL-37, fengycin 2B, and magainin-2. The minimum inhibitory concentration (MIC) was determined by microdilution technique according to CLSI (M07-A9, 2012) against Escherichia coli , methicillin-resistant Staphy...

Full description

Saved in:
Bibliographic Details
Published in:Brazilian journal of microbiology 2022-03, Vol.53 (1), p.171-177
Main Authors: Denardi, Laura Bedin, de Arruda Trindade, Priscila, Weiblen, Carla, Ianiski, Lara Baccarin, Stibbe, Paula Cristina, Pinto, Stefania Campos, Santurio, Janio Morais
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial activity
Antibacterial agents
Antibiotic resistance
Antibiotics
Antimicrobial agents
Antimicrobial peptides
Antimicrobial Peptides - pharmacology
Bacteria
Bacteria - drug effects
Bactericidal activity
Biomedical and Life Sciences
Clinical Microbiology - Research Paper
Drug resistance
E coli
Food Microbiology
Klebsiella
Life Sciences
Lipopeptides - pharmacology
Magainins - pharmacology
Medical Microbiology
Methicillin
Microbial Ecology
Microbial Genetics and Genomics
Microbial Sensitivity Tests
Microbiology
Minimum inhibitory concentration
Mycology
Peptides
Pseudomonas aeruginosa
Staphylococcus infections
Strains (organisms)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We investigated the antibacterial activity of the antimicrobial peptides h-Lf1-11, MSI-78, LL-37, fengycin 2B, and magainin-2. The minimum inhibitory concentration (MIC) was determined by microdilution technique according to CLSI (M07-A9, 2012) against Escherichia coli , methicillin-resistant Staphylococcus aureus , Pseudomonas aeruginosa , carbapenem-resistant Klebsiella pneumoniae , and Acinetobacter baumannii . The MSI-78 showed potent bactericidal activity with MIC range of 1.25–40 mg/L against all bacterial strains. The h-Lf1-11, magainin-2, and LL-37 exhibited moderate activity (MIC range of 40–160, 80–160, and 40–160 mg/L, respectively) while the fengycin 2B did not show significant activity against all bacterial strains tested. These results revealed that MSI-78, h-Lf1-11, magainin-2, and LL-37 have great potential as antibacterial agents and their activity deserves to be more explored in further studies for the treatment of antibiotic-resistant bacteria.
ISSN:1517-8382
1678-4405
DOI:10.1007/s42770-021-00645-6