The impact of CNS-directed treatment on quality of life in childhood cancer survivors

• Published in: Quality of life research 2022-03, Vol.31 (3), p.817-829
• Main Authors: Lipak, Keagan G., Rausch, Joseph R., Fisher, Rachel S., Prussien, Kemar V., Clark, Olivia E., Kenney, Ansley E., Himelhoch, Alexandra C., Olshefski, Randal S., Nahata, Leena, Vannatta, Kathryn, Compas, Bruce E., Gerhardt, Cynthia A.
• Format: Article
• Language: English
• Subjects: Adolescent; Cancer; Cancer Survivors; Child; Child, Preschool; Childhood; Female; Humans; Male; Males; Medicine; Medicine & Public Health; Neoplasms - drug therapy; Public Health; Quality of life; Quality of Life - psychology; Quality of Life Research; Sociology; Surveys and Questionnaires; Survivors; Survivorship
• ISSN: 0962-9343; 1573-2649
• DOI: 10.1007/s11136-021-02984-1

Purpose Pediatric cancer survivors may have lower quality of life (QoL), but most research has assessed outcomes either in treatment or long-term survivorship. We focused on early survivorship (i.e., 3 and 5 years post-diagnosis), examining the impact of CNS-directed treatment on child QoL, as well as sex and age at diagnosis as potential moderators. Methods Families of children with cancer (ages 5–17) were recruited at diagnosis or relapse ( N  = 336). Survivors completed the PedsQL at 3 ( n  = 96) and 5 years ( n  = 108), along with mothers (101 and 105, respectively) and fathers (45 and 53, respectively). The impact of CNS treatment, sex, and age at diagnosis on child QoL was examined over both time since diagnosis and time since last treatment using mixed model analyses. Results Parent-report of the child’s total QoL was in the normative range and stable between 3 and 5 years when examining time since diagnosis, while child reported QoL improved over time ( p  = 0.04). In terms of time since last treatment, mother and child both reported the child’s QoL improved over time ( p  = 0.0002 and p  = 0.0006, respectively). Based on parent-report, males with CNS-directed treatment had lower total QoL than females and males who did not receive CNS-directed treatment. Age at diagnosis did not moderate the impact of treatment type on total QoL. Conclusions Quality of life (QoL) in early survivorship may be low among males who received CNS-directed treatment. However, this was only evident on parent-report. Interventions to improve child QoL should focus on male survivors who received CNS-directed treatment, as well as females regardless of treatment type.