Association between arthritis treatments and ovarian reserve: a prospective study

•Women with arthritis had lower anti-Müllerian hormone (AMH) than healthy controls.•AMH concentration was not associated with disease severity or arthritis drug regimens.•Long-term methotrexate was not associated with low ovarian reserve in arthritis patients. How do anti-Müllerian hormone (AMH) con...

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Bibliographic Details
Published in:Reproductive biomedicine online 2021-06, Vol.42 (6), p.1203-1210
Main Authors: Alexander, Vinita M., Ashley-Martin, Jillian, Riley, Joan K., Cooper, Amber R., Ratts, Valerie S., Jungheim, Emily S.
Format: Article
Language:English
Subjects:
Adult
Anti-Mullerian Hormone - blood
Antirheumatic Agents - adverse effects
Arthritis
Arthritis - blood
Arthritis - drug therapy
Case-Control Studies
Female
Humans
Methotrexate
Methotrexate - adverse effects
Ovarian reserve
Ovarian Reserve - drug effects
Prospective Studies
Young Adult
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Summary:•Women with arthritis had lower anti-Müllerian hormone (AMH) than healthy controls.•AMH concentration was not associated with disease severity or arthritis drug regimens.•Long-term methotrexate was not associated with low ovarian reserve in arthritis patients. How do anti-Müllerian hormone (AMH) concentrations in women with and without arthritis compare? Is there an association between AMH and arthritis drug regimen? In this prospective cohort study, AMH was measured at two time points (T0 and T1) in 129 premenopausal women with arthritis. AMH at T0 was compared with that from a bank of serum samples from 198 premenopausal women without arthritis. Primary outcomes were: (i) diminished ovarian reserve (DOR) (AMH
ISSN:1472-6483
1472-6491
DOI:10.1016/j.rbmo.2021.03.018