Treatment with Light-Emitting Diodes of Wavelength 863 nm Delays DMBA/TPA-Induced Skin Tumor Formation and Decreases Proinflammatory Cytokine Levels in ICR Mice

The popularity of light/energy devices for cosmetic purposes (e.g., skin care) is increasing. However, the effects and underlying mechanisms remain poorly understood. Commencing in the 1960s, various studies have evaluated the beneficial effects of a light source on cells and tissues. The techniques...

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Bibliographic Details
Published in:BioMed research international 2022, Vol.2022, p.4400276-10
Main Authors: Park, Hyeong Ju, Cho, Yeon Hee, Goo, Hyeyoon, Choi, Sun-hyang, Kim, Eun Young, Hong, Namgue, Mo, SangJoon, Park, Ji On, Lee, Byeong-Il, Lee, Min Young, Ahn, Jin-Chul
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Arrays
Cytokines
Inflammation
Infrared radiation
Infrared Rays
Lasers
Light emitting diodes
Light sources
Light therapy
Low-Level Light Therapy - methods
Mice
Mice, Inbred ICR
Skin
Skin cancer
Skin care
Skin Neoplasms - chemically induced
Statistical analysis
Thyroid cancer
Tumors
Wavelength
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Summary:The popularity of light/energy devices for cosmetic purposes (e.g., skin care) is increasing. However, the effects and underlying mechanisms remain poorly understood. Commencing in the 1960s, various studies have evaluated the beneficial effects of a light source on cells and tissues. The techniques evaluated include low-level light (laser) therapy and photobiomodulation (PBM). Most studies on PBM used red light sources, but, recently, many studies have employed near-infrared light sources including those of wavelength 800 nm. Here, we used a light-emitting diode (LED) array with a wavelength of 863 nm to treat DMBA/TPA-induced mouse skin tumors; treatment with the array delayed tumor development and reduced the levels of systemic inflammatory cytokines. These results suggest that light therapy could be beneficial. However, the effects were small. Further studies on different skin tumors using an optimized LED setup are required. Combination therapies (conventional methods and an LED array) may be useful.
ISSN:2314-6133
2314-6141
DOI:10.1155/2022/4400276