The modulation of neuroinflammation by inducible nitric oxide synthase

The accumulation and propagation of misfolded proteins in the brain is a pathological hallmark shared by many neurodegenerative diseases, such as the depositions of β-amyloid and hyperphosphorylated tau proteins in Alzheimer's disease. Initial evidence shows the role of nitric oxide synthases i...

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Bibliographic Details
Published in:Journal of cell communication and signaling 2022-06, Vol.16 (2), p.155-158
Main Authors: Justo, Alberto Fernando Oliveira, Suemoto, Claudia Kimie
Format: Article
Language:English
Subjects:
Alzheimer's disease
Biomedical and Life Sciences
Biomedicine
Bits and Bytes
Cell Biology
Inflammation
iNOS
Life Sciences
Neurodegeneration
Neurodegenerative diseases
Neuromodulation
Nitrergic stress
Nitric oxide
Nitric-oxide synthase
Oxidative stress
Prion model
Protein folding
Synaptic strength
Tau protein
β-Amyloid
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Summary:The accumulation and propagation of misfolded proteins in the brain is a pathological hallmark shared by many neurodegenerative diseases, such as the depositions of β-amyloid and hyperphosphorylated tau proteins in Alzheimer's disease. Initial evidence shows the role of nitric oxide synthases in the development of neurodegenerative diseases. A recent, in an exciting paper (Bourgognon et al. in Proc Natl Acad Sci USA 118, 1–11, 2021. 10.1073/pnas.2009579118) it was shown that the inducible nitric oxide synthase plays an important role in promoting oxidative and nitrergic stress leading to neuroinflammation and consequently neuronal function impairments and decline in synaptic strength in mouse prion disease. In this context, we reviewed the possible mechanisms of nitric oxide synthase in the generation of neurodegenerative diseases.
ISSN:1873-9601
1873-961X
DOI:10.1007/s12079-021-00663-x