Subclinical involvement of the trunk muscles in idiopathic inflammatory myopathies

Background Whole-body magnetic resonance imaging (WB-MRI) is a useful tool for revealing the disease-specific distribution of affected muscles and clinically asymptomatic muscle involvements in idiopathic inflammatory myopathies (IIMs). Purpose To examine inflammatory changes in the systemic skeleta...

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Bibliographic Details
Published in:Acta radiologica open 2022-02, Vol.11 (2), p.20584601221075796-20584601221075796
Main Authors: Matsuda, Nozomu, Kobayashi, Shunsuke, Hasegawa, Osamu, Yoshida, Kenji, Kubo, Hitoshi, Ugawa, Yoshikazu, Kanai, Kazuaki
Format: Article
Language:English
Subjects:
Abdomen
Antibodies
Asymptomatic
Biomarkers
Creatine
Creatine kinase
Inflammation
Inflammatory diseases
Kinases
Magnetic resonance imaging
Medical imaging
Muscle strength
Muscles
Musculoskeletal diseases
Myopathy
Myositis
Original
Recovery (Medical)
Skeletal muscle
Trunk muscles
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Summary:Background Whole-body magnetic resonance imaging (WB-MRI) is a useful tool for revealing the disease-specific distribution of affected muscles and clinically asymptomatic muscle involvements in idiopathic inflammatory myopathies (IIMs). Purpose To examine inflammatory changes in the systemic skeletal muscles, including the thoracoabdominal trunk, in IIMs using WB-MRI. Material and Methods We prospectively obtained WB-MRI axial images from 10 patients with IIMs, including antisynthetase syndrome (ASS), immune-mediated necrotizing myopathy (IMNM), sporadic inclusion body myositis, and myopathy associated with antimitochondrial antibody. We evaluated 108 systemic skeletal muscles in short-tau inversion recovery (STIR) images and rated changes in signal intensity using a semiquantitative scale. Correlations between STIR sum score, peak creatine kinase (CK) and muscle strength were examined. We also investigated the correlation between STIR sum score within the thoracoabdominal trunk and forced vital capacity. Results High STIR signal changes were frequently identified in asymptomatic and routinely unexamined muscles. Thoracoabdominal trunk muscles were frequently involved in ASS and IMNM. Peak CK was positively correlated with the STIR sum score (R2 = 0.62, p < .01). There was no significant correlation between the STIR sum score within the thoracoabdominal trunk and forced vital capacity. Conclusion WB-MRI can detect subclinical muscle inflammation in the systemic muscles including the trunk muscles. STIR sum score is positively correlated with serum peak CK level; therefore, it could be a biomarker of overall muscle inflammation.
ISSN:2058-4601
2058-4601
DOI:10.1177/20584601221075796