Anesthetics affect peripheral venous pressure waveforms and the cross-talk with arterial pressure

Analysis of peripheral venous pressure (PVP) waveforms is a novel method of monitoring intravascular volume. Two pediatric cohorts were studied to test the effect of anesthetic agents on the PVP waveform and cross-talk between peripheral veins and arteries: (1) dehydration setting in a pyloromyotomy...

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Bibliographic Details
Published in:Journal of clinical monitoring and computing 2022-02, Vol.36 (1), p.147-159
Main Authors: Al-Alawi, Ali Z., Henry, Kaylee R., Crimmins, Lauren D., Bonasso, Patrick C., Hayat, Md Abul, Dassinger, Melvin S., Burford, Jeffrey M., Jensen, Hanna K., Sanford, Joseph, Wu, Jingxian, Sexton, Kevin W., Jensen, Morten O.
Format: Article
Language:English
Subjects:
Anesthesia
Anesthesiology
Anesthetics
Arteries
Birth defects
Blood
Critical Care Medicine
Crosstalk
Dehydration
Health Sciences
Heart rate
Hemorrhage
Intensive
Medicine
Medicine & Public Health
Monitoring
Original Research
Patients
Pediatrics
Prediction models
Respiratory rate
Statistics for Life Sciences
Surgery
Variance analysis
Veins
Veins & arteries
Vital signs
Waveforms
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Summary:Analysis of peripheral venous pressure (PVP) waveforms is a novel method of monitoring intravascular volume. Two pediatric cohorts were studied to test the effect of anesthetic agents on the PVP waveform and cross-talk between peripheral veins and arteries: (1) dehydration setting in a pyloromyotomy using the infused anesthetic propofol and (2) hemorrhage setting during elective surgery for craniosynostosis with the inhaled anesthetic isoflurane. PVP waveforms were collected from 39 patients that received propofol and 9 that received isoflurane. A multiple analysis of variance test determined if anesthetics influence the PVP waveform. A prediction system was built using k-nearest neighbor (k-NN) to distinguish between: (1) PVP waveforms with and without propofol and (2) different minimum alveolar concentration (MAC) groups of isoflurane. 52 porcine, 5 propofol, and 7 isoflurane subjects were used to determine the cross-talk between veins and arteries at the heart and respiratory rate frequency during: (a) during and after bleeding with constant anesthesia, (b) before and after propofol, and (c) at each MAC value. PVP waveforms are influenced by anesthetics, determined by MANOVA: p value  
ISSN:1387-1307
1573-2614
DOI:10.1007/s10877-020-00632-6