Dissimilarity in the Chemical Behavior of Osmaoxazolium Salts and Osmaoxazoles: Two Different Aromatic Metalladiheterocycles

• Published in: Organometallics 2021-12, Vol.40 (24), p.4150-4162
• Main Authors: Buil, María L, Esteruelas, Miguel A, Oñate, Enrique, Picazo, Nieves R
• Format: Article
• Language: English
• ISSN: 0276-7333; 1520-6041
• DOI: 10.1021/acs.organomet.1c00621

The preparation of aromatic hydride-osmaoxazolium and hydride-oxazole compounds is reported and their reactivity toward phenylacetylene investigated. Complex [OsH­(OH)­(CPh)­(IPr)­(PiPr3)]­OTf (1; IPr = 1,3-bis­(2,6-diisopropylphenyl)­imidazolylidene, OTf = CF3SO3) reacts with acetonitrile and benzonitrile to give [OsH­{κ2-C,O-[C­(Ph)­NHC­(R)­O]}­(NCR)­(IPr)­(PiPr3)]­OTf (R = Me (2), Ph (3)) via amidate intermediates, which are generated by addition of the hydroxide ligand to the nitrile. In agreement with this, the addition of 2-phenylacetamide to acetonitrile solutions of 1 gives [OsH­{κ2-C,O-[C­(Ph)­NHC­(CH2Ph)­O]}­(NCCH3)­(IPr)­(PiPr3)]­OTf (4). The deprotonation of the osmaoxazolium ring of 2 and 4 leads to the oxazole derivatives OsH­{κ2-C,O-[C­(Ph)­NC­(R)­O]}­(IPr)­(PiPr3) (R = Me (5), CH2Ph (6)). Complexes 2 and 4 add their Os–H and Os–C bonds to the C–C triple bond of phenylacetylene to afford [Os­{η3-C 3 ,κ1-O-[CH2C­(Ph)­C­(Ph)­NHC­(R)­O]}­(NCCH3)2(IPr)]­OTf (R = Me (7), CH2Ph (8)), bearing a tridentate amide-N-functionalized allyl ligand, while complexes 5 and 6 undergo a vicarious nucleophilic substitution of the hydride at the metal center with the alkyne, via the compressed dihydride adduct intermediates OsH2(CCPh)­{κ2-C,O-[C­(Ph)­NC­(R)­O]}­(IPr)­(PiPr3) (R = Me (9), CH2Ph (10)), which reductively eliminate H2 to yield the acetylide-osmaoxazoles Os­(CCPh)­{κ2-C,O-[C­(Ph)­NC­(R)­O]}­(IPr)­(PiPr3) (R = Me (11), CH2Ph (12)).