Serum Heat Shock Protein 70 Level in Children with Attention Deficiency Hyperactivity Disorder

• Published in: Noro-Psikiyatri Arsivi 2022-03, Vol.59 (1), p.63-67
• Main Authors: Özaslan, Ahmet, Güney, Esra, Gülbahar, Özlem, Büyüktaşkin Tunçtürk, Dicle, Arslan, Burak, Güveli Bozkurt, Güner Melike
• Format: Article
• Language: English
• Subjects: Apoptosis; Attention deficit hyperactivity disorder; Autism; Child & adolescent psychiatry; Child psychology; Development and progression; Diagnosis; Enzymes; Etiology; Health aspects; Heat shock proteins; Hyperactivity; Measurement; Mental depression; Mental disorders; Outpatient care facilities; Oxidative stress; Pathophysiology; Pediatric research; Physiology; Schizophrenia
• ISSN: 1300-0667; 1309-4866
• DOI: 10.29399/npa.27652

Attention deficit hyperactivity disorder (ADHD) have quite complicated etiology. The relationship between ADHD and immune and oxidative imbalances is discussed in current researches investigating the pathophysiology of ADHD. The aim of the study is to determine whether heat shock protein 70 (HSP70) has a potential role in pathophysiologic mechanisms of attention deficit hyperactivity disorder. This study included 41 children that were diagnosed with ADHD and 32 typically developing children. Conners' Teacher Rating Scale (CTRS) was used to evaluate ADHD presentation and severity. Additionally, an enzyme-linked immunosorbent assay (ELISA) kit was used to evaluate serum HSP70 level. We have detected that the serum HSP70 levels of children with ADHD were lower than the typically developing group (p0.05). With these findings, it can be proposed that HSP70 might have a crucial role in the etiological mechanisms of ADHD. Moreover, these changes in peripheral blood may have therapeutic and/or diagnostic value. However, more detailed prospective studies are needed to explain the link between ADHD and heat shock proteins.