Heart regeneration: 20 years of progress and renewed optimism

Cardiovascular disease is a leading cause of death worldwide, and thus there remains great interest in regenerative approaches to treat heart failure. In the past 20 years, the field of heart regeneration has entered a renaissance period with remarkable progress in the understanding of endogenous he...

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Bibliographic Details
Published in:Developmental cell 2022-02, Vol.57 (4), p.424-439
Main Authors: Garbern, Jessica C., Lee, Richard T.
Format: Article
Language:English
Subjects:
Animals
cardiomyocyte proliferation
Heart - physiology
heart regeneration
Humans
Myocardium - cytology
Myocytes, Cardiac - cytology
Regeneration - physiology
Regenerative Medicine - methods
reprogramming
Stem Cell Transplantation - methods
stem cells
tissue engineering
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Summary:Cardiovascular disease is a leading cause of death worldwide, and thus there remains great interest in regenerative approaches to treat heart failure. In the past 20 years, the field of heart regeneration has entered a renaissance period with remarkable progress in the understanding of endogenous heart regeneration, stem cell differentiation for exogenous cell therapy, and cell-delivery methods. In this review, we highlight how this new understanding can lead to viable strategies for human therapy. For the near term, drugs, electrical and mechanical devices, and heart transplantation will remain mainstays of cardiac therapies, but eventually regenerative therapies based on fundamental regenerative biology may offer more permanent solutions for patients with heart failure. Cardiovascular disease is a leading cause of death, and there is therefore great interest in regenerative approaches to treat heart failure. Garbern and Lee review the remarkable recent progress in the field of heart regeneration and discuss how this improved understanding can lead to viable strategies for human therapy.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2022.01.012