The Role of Symptom Duration and Serologic Factors in the Relapse of IgG4-Related Ophthalmic Disease following Surgery: A Retrospective Cohort Study

IgG4-related disease (IgG4-RD) affects multiple organs and is characterized by immune-mediated inflammation and fibrosis; IgG-RD affecting orbital tissue is known as IgG4-related ophthalmic disease (IgG4-ROD). This research is aimed at exploring whether symptom duration and common serologic factors,...

Full description

Saved in:
Bibliographic Details
Published in:Disease markers 2022, Vol.2022, p.5651506-9
Main Authors: Liu, Siyu, Yue, Zifan, Zeng, Chengcheng, Huang, Xiao, Li, Jian, Diao, Jiale, Chen, Xinxin, Wei, Ruili, Yang, Weihua
Format: Article
Language:English
Subjects:
Adult
Aged
Asthma
Biomarkers - blood
Cohort analysis
Disease
Eosinophils
Eosinophils - metabolism
Exocrine glands
Eye Diseases - blood
Eye Diseases - diagnosis
Eye Diseases - immunology
Eye Diseases - surgery
Female
Fibrosis
Follow-Up Studies
Health risks
Hospitals
Humans
Immunoglobulin E
Immunoglobulin E - blood
Immunoglobulin G
Immunoglobulin G - blood
Immunoglobulin G4-Related Disease - blood
Immunoglobulin G4-Related Disease - diagnosis
Immunoglobulin G4-Related Disease - immunology
Immunoglobulin G4-Related Disease - surgery
Inspection
Kaplan-Meier Estimate
Laboratories
Leukocytes (eosinophilic)
Male
Medical diagnosis
Middle Aged
Organs
Patients
Rank tests
Recurrence
Retrospective Studies
Risk analysis
Risk factors
Serology
Surgery
Survival
Survival analysis
Time Factors
Treatment Outcome
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:IgG4-related disease (IgG4-RD) affects multiple organs and is characterized by immune-mediated inflammation and fibrosis; IgG-RD affecting orbital tissue is known as IgG4-related ophthalmic disease (IgG4-ROD). This research is aimed at exploring whether symptom duration and common serologic factors, such as IgG, IgE, and eosinophils, are potential risk factors for IgG4-ROD patient relapse after surgery and identifying possible causes of the positive correlation between symptom duration and relapse. This retrospective cohort study included 40 IgG4-ROD patients after surgery. Auxiliary inspection results were obtained before surgery and during follow-up, and relapse risk factors were identified based on previous studies. We used the Spearman rank correlation test to reveal the relationship between symptom duration and relapse time and identified the optimal cutoff value for symptom duration by X-tile. Then, we divided the patients into the long-duration and short-duration groups. Kaplan–Meier survival analyses and log-rank tests were performed to identify the relationship between symptom duration and relapse using X-tile software. Finally, we studied the relationship between previously studied relapse risk factors and symptom duration. The survival curves of the long-duration and short-duration groups were obviously different, and the baseline serum IgG, IgE, and eosinophil levels and asthma concomitant rate were significantly different between the long-duration and short-duration groups. Furthermore, the baseline serum IgG (r=0.485, P=0.002), IgE (r=0.350, P=0.037), and eosinophil (r=0.6535, P
ISSN:0278-0240
1875-8630
DOI:10.1155/2022/5651506