The role of central autonomic nervous system dysfunction in Takotsubo syndrome: a systematic review

Introduction Takotsubo syndrome (TTS), also known as stress cardiomyopathy or “broken heart” syndrome, is a mysterious condition that often mimics an acute myocardial infarction. Both are characterized by left ventricular systolic dysfunction. However, this dysfunction is reversible in the majority...

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Bibliographic Details
Published in:Clinical autonomic research 2022-02, Vol.32 (1), p.9-17
Main Authors: Brazdil, Vojtech, Kala, Petr, Hudec, Martin, Poloczek, Martin, Kanovsky, Jan, Stipal, Roman, Jerabek, Petr, Bocek, Otakar, Pail, Martin, Brazdil, Milan
Format: Article
Language:English
Subjects:
Autonomic Nervous System
Brain
Cardiology
Cardiomyopathy
Central nervous system
Diabetes
Endocrinology
Gastroenterology
Heart
Heart attacks
Humans
Medicine
Medicine & Public Health
Myocardial infarction
Nervous system
Neural networks
Neurology
Ophthalmology
Prognosis
Review
Review Article
Structure-function relationships
Takotsubo Cardiomyopathy - etiology
Ventricle
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Summary:Introduction Takotsubo syndrome (TTS), also known as stress cardiomyopathy or “broken heart” syndrome, is a mysterious condition that often mimics an acute myocardial infarction. Both are characterized by left ventricular systolic dysfunction. However, this dysfunction is reversible in the majority of TTS patients. Purpose Recent studies surprisingly demonstrated that TTS, initially perceived as a benign condition, has a long-term prognosis akin to myocardial infarction. Therefore, the health consequences and societal impact of TTS are not trivial. The pathophysiological mechanisms of TTS are not yet completely understood. In the last decade, attention has been increasingly focused on the putative role of the central nervous system in the pathogenesis of TTS. Conclusion In this review, we aim to summarize the state of the art in the field of the brain–heart axis, regional structural and functional brain abnormalities, and connectivity aberrancies in TTS.
ISSN:0959-9851
1619-1560
DOI:10.1007/s10286-021-00844-z