CBX3 is associated with metastasis and glutathione/glycosphingolipid metabolism in colon adenocarcinoma

Metastasis is the major cause of colon adenocarcinoma (COAD) mortality. Increasing studies demonstrated that the epigenetics and downstream expression change of pivotal genes may act as a major role in promoting COAD progression and metastasis. Therefore, identifying the dysregulation of key genes a...

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Bibliographic Details
Published in:Journal of gastrointestinal oncology 2022-02, Vol.13 (1), p.246-255
Main Authors: Zhong, Xiaoling, Ni, Jun, Jia, Zhijun, Yan, Hong, Zhang, Ying, Liu, Yunyun
Format: Article
Language:English
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Summary:Metastasis is the major cause of colon adenocarcinoma (COAD) mortality. Increasing studies demonstrated that the epigenetics and downstream expression change of pivotal genes may act as a major role in promoting COAD progression and metastasis. Therefore, identifying the dysregulation of key genes associating with COAD metastasis may provide a new strategy for the discovery of potential treatment targets. This study included a single-cell RNA sequencing profile consisting of 17,469 tumor cells derived from 23 samples, and 326 COADs available from The Cancer Genome Atlas (TCGA), etc. The study was performed using comparative analysis to characterize the role of in COAD metastasis and progression. This study revealed that the mRNA level of Chromebox homolog 3 ( ) in the metastatic COAD was significantly higher than that of the primary COAD and normal colon tissues (Wilcoxon's rank-sum test, P
ISSN:2078-6891
2219-679X
DOI:10.21037/jgo-22-97