Immunomodulatory properties of CNF1 toxin from E. coli : implications for colorectal carcinogenesis

Colorectal cancer (CRC) is a leading cause of cancer death worldwide. The risk of developing CRC is influenced by both environmental and genetic factors. Recently, chronic inflammation and gut microbiota modifications have been associated with increased CRC risk. belongs to the commensal intestinal...

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Bibliographic Details
Published in:American journal of cancer research 2022-01, Vol.12 (2), p.651-660
Main Authors: Fabbri, Alessia, Bracci, Laura
Format: Article
Language:English
Subjects:
Review
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Summary:Colorectal cancer (CRC) is a leading cause of cancer death worldwide. The risk of developing CRC is influenced by both environmental and genetic factors. Recently, chronic inflammation and gut microbiota modifications have been associated with increased CRC risk. belongs to the commensal intestinal flora and can become highly pathogenic following the acquisition of genes coding for virulence factors, such as the cytotoxic necrotizing factor type 1 (CNF1). Numerous reports highlight that, besides exerting direct effects on epithelial cells, CNF1 can also act on immune cells, modulating their responses and possibly contributing to disease development. In the present review, we summarized the key studies addressing the immunomodulatory functions of CNF1 and discussed the contribution that CNF1 can bring about to CRC through the creation of a pro-inflammatory microenvironment.
ISSN:2156-6976
2156-6976