Aberrations in SMAD family of genes among HNSCC patients

Head and neck cancer is a debilitating disease with several etiological factors. One of the main etiologies to be noticed is the alteration, which is either caused by genetic or environmental factors. Therefore, it is of interest to assess the effect of genetic alterations, especially the non-synony...

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Bibliographic Details
Published in:Bioinformation 2021-12, Vol.17 (12), p.113-1119
Main Authors: Thariny, E, Smiline Girija, A M, Paramasivam, A, Vijayashree Priyadharsini, J
Format: Article
Language:English
Subjects:
Cancer
Environmental factors
Etiology
Head & neck cancer
Head and neck carcinoma
Mutation
Smad protein
Squamous cell carcinoma
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Summary:Head and neck cancer is a debilitating disease with several etiological factors. One of the main etiologies to be noticed is the alteration, which is either caused by genetic or environmental factors. Therefore, it is of interest to assess the effect of genetic alterations, especially the non-synonymous mutations of the SMAD gene family and its possible association with HNSCC. Data shows a significant novel mutation in the SMAD gene family in association with head and neck squamous cell carcinoma (HNSCC), which would aid in better diagnosis and treatment planning for cancer.
ISSN:0973-2063
0973-8894
0973-2063
DOI:10.6026/973206300171113