Granulomatosis with polyangiitis following Pfizer-BioNTech COVID-19 vaccination

We report the first case of proteinase 3-antineutrophil cytoplasmic antibody-positive granulomatosis with polyangiitis (GPA) with predominant ears, nose, and throat manifestations following coronavirus disease 2019 (COVID-19) vaccination. A 63-year-old woman presented with aural fullness 3 days afte...

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Bibliographic Details
Published in:Modern rheumatology case reports 2023-01, Vol.7 (1), p.127-129
Main Authors: Shirai, Tsuyoshi, Suzuki, Jun, Kuniyoshi, Shimpei, Tanno, Yuito, Fujii, Hiroshi
Format: Article
Language:English
Subjects:
Antibodies, Antineutrophil Cytoplasmic
Case Report
COVID-19 - diagnosis
COVID-19 - prevention & control
COVID-19 Vaccines - adverse effects
Female
Granulomatosis with Polyangiitis - diagnosis
Granulomatosis with Polyangiitis - etiology
Humans
Middle Aged
Myeloblastin
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Summary:We report the first case of proteinase 3-antineutrophil cytoplasmic antibody-positive granulomatosis with polyangiitis (GPA) with predominant ears, nose, and throat manifestations following coronavirus disease 2019 (COVID-19) vaccination. A 63-year-old woman presented with aural fullness 3 days after vaccination. She presented with progressive rhinosinusitis and otitis media leading to profound hearing loss within 3 weeks. Clinical imaging revealed soft-tissue shadows in the paranasal sinuses with multiple pulmonary nodules, and histopathology was consistent with a diagnosis of GPA. It is crucial to be wary of the possibility of GPA in patients who received COVID-19 vaccines due to its rapid disease progression.
ISSN:2472-5625
2472-5625
DOI:10.1093/mrcr/rxac016