Kynurenine pathway in Coronavirus disease (COVID‐19): Potential role in prognosis

• Published in: Journal of Clinical Laboratory Analysis 2022-03, Vol.36 (3), p.e24257-n/a
• Main Authors: Cihan, Murat, Doğan, Özlem, Ceran Serdar, Ceyhan, Altunçekiç Yıldırım, Arzu, Kurt, Celali, Serdar, Muhittin A.
• Format: Article
• Language: English
• Subjects: Acids; Adult; Aged; Asymptomatic; Comorbidity; Coronaviruses; coronavirus‐19 disease (COVID‐19); COVID-19; COVID-19 - diagnosis; COVID-19 - epidemiology; COVID-19 - metabolism; COVID-19 - physiopathology; Cytokine storm; Dendritic cells; Disease; Female; Ferritin; Humans; Immune system; Infections; Inflammation; Intensive care; Kynurenic acid; Kynurenic Acid - blood; Kynurenine - metabolism; kynurenine pathway; Laboratories; Male; Mass spectroscopy; Metabolites; Middle Aged; Multiple organ dysfunction syndrome; Patients; Picolinic acid; Picolinic Acids - blood; Pneumonia; Procalcitonin; Prognosis; Quinolinic acid; Quinolinic Acid - blood; Respiratory distress syndrome; Sample size; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Software; Statistical analysis; Tryptophan; Tryptophan - blood; Tumor necrosis factor-TNF; Viral infections
• ISSN: 0887-8013; 1098-2825
• DOI: 10.1002/jcla.24257

Background It is known that inflammatory responses play an important role in the pathophysiology of COVID‐19. Aims In this study, we aimed to examine the role of kynurenine (KYN) metabolism on the severity of COVID‐19 disease AQ5. Materials & Methods Seventy COVID‐19 patients of varying severity and 30 controls were included in the study. In addition to the classical laboratory parameters, KYN, tryptophan (TRP), kynurenic acid (KYNA), 3 hydroxykynurenine (3OHKYN), quinolinic acid (QA), and picolinic acid (PA) were measured with mass spectrometry. Results TRP, KYN, KYN:TRP ratio, KYNA, 3OHKYN, PA, and QA results were found to be significantly different in COVID‐19 patients (p