Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA

Abstract We report a case of resistance development toward cefiderocol in a patient with intra-abdominal and bloodstream infections caused by carbapenemase-producing Enterobacter cloacae within 21 days of cefiderocol therapy. Whole genome sequencing revealed heterogeneous mutations in the cirA gene,...

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Published in:Clinical infectious diseases 2022-03, Vol.74 (5), p.905-908
Main Authors: Klein, Sabrina, Boutin, Sébastien, Kocer, Kaan, Fiedler, Mascha O, Störzinger, Dominic, Weigand, Markus A, Tan, Benjamin, Richter, Daniel, Rupp, Christian, Mieth, Markus, Mehrabi, Arianeb, Hackert, Thilo, Zimmermann, Stefan, Heeg, Klaus, Nurjadi, Dennis
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Bacterial Proteins - genetics
beta-Lactamases - genetics
Brief Reports
Carbapenems - pharmacology
Carbapenems - therapeutic use
Cefiderocol
Cephalosporins
Enterobacter cloacae - genetics
Humans
Microbial Sensitivity Tests
Mutation
Siderophores - therapeutic use
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cited_by cdi_FETCH-LOGICAL-c412t-fdb35c41455acbaed7f84ce9633f4e2b72d2681507938c830c0dc4c5c3df493e3
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container_title Clinical infectious diseases
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creator Klein, Sabrina
Boutin, Sébastien
Kocer, Kaan
Fiedler, Mascha O
Störzinger, Dominic
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Tan, Benjamin
Richter, Daniel
Rupp, Christian
Mieth, Markus
Mehrabi, Arianeb
Hackert, Thilo
Zimmermann, Stefan
Heeg, Klaus
Nurjadi, Dennis
description Abstract We report a case of resistance development toward cefiderocol in a patient with intra-abdominal and bloodstream infections caused by carbapenemase-producing Enterobacter cloacae within 21 days of cefiderocol therapy. Whole genome sequencing revealed heterogeneous mutations in the cirA gene, encoding a catecholate siderophore receptor, conferring phenotypic resistance to cefiderocol.
doi_str_mv 10.1093/cid/ciab511
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ispartof Clinical infectious diseases, 2022-03, Vol.74 (5), p.905-908
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source Oxford Journals Online
subjects Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Bacterial Proteins - genetics
beta-Lactamases - genetics
Brief Reports
Carbapenems - pharmacology
Carbapenems - therapeutic use
Cefiderocol
Cephalosporins
Enterobacter cloacae - genetics
Humans
Microbial Sensitivity Tests
Mutation
Siderophores - therapeutic use
title Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA
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