A Designer Quest for the Achilles' Heel of Influenza

Monoclonal antibodies are attractive but, in certain applications, limited therapeutic modalities due to their large size and high specificity. In this issue of Structure, Sevy at al. describe a computationally designed cyclic peptide mimicking the CDRH3 loop of the C05 antibody against influenza sh...

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Bibliographic Details
Published in:Structure (London) 2020-10, Vol.28 (10), p.1083-1084
Main Authors: Fajardo, J Eduardo, Fiser, Andras
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal
Biophysical Phenomena
Humans
Influenza, Human - diagnosis
Peptides, Cyclic
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Online Access:Get full text
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Summary:Monoclonal antibodies are attractive but, in certain applications, limited therapeutic modalities due to their large size and high specificity. In this issue of Structure, Sevy at al. describe a computationally designed cyclic peptide mimicking the CDRH3 loop of the C05 antibody against influenza showing the potential utility of designer biologics.
ISSN:0969-2126
1878-4186
DOI:10.1016/j.str.2020.09.004