A Designer Quest for the Achilles' Heel of Influenza

Monoclonal antibodies are attractive but, in certain applications, limited therapeutic modalities due to their large size and high specificity. In this issue of Structure, Sevy at al. describe a computationally designed cyclic peptide mimicking the CDRH3 loop of the C05 antibody against influenza sh...

Full description

Saved in:
Bibliographic Details
Published in:Structure (London) 2020-10, Vol.28 (10), p.1083-1084
Main Authors: Fajardo, J Eduardo, Fiser, Andras
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal
Biophysical Phenomena
Humans
Influenza, Human - diagnosis
Peptides, Cyclic
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c351t-fa030198169e7da0e89505bdf3b5e5229bbf55934f75677e3f58c57bc7f07a4d3
container_end_page 1084
container_issue 10
container_start_page 1083
container_title Structure (London)
container_volume 28
creator Fajardo, J Eduardo
Fiser, Andras
description Monoclonal antibodies are attractive but, in certain applications, limited therapeutic modalities due to their large size and high specificity. In this issue of Structure, Sevy at al. describe a computationally designed cyclic peptide mimicking the CDRH3 loop of the C05 antibody against influenza showing the potential utility of designer biologics.
doi_str_mv 10.1016/j.str.2020.09.004
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8908349</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2449260337</sourcerecordid><originalsourceid>FETCH-LOGICAL-c351t-fa030198169e7da0e89505bdf3b5e5229bbf55934f75677e3f58c57bc7f07a4d3</originalsourceid><addsrcrecordid>eNpVkM1OwzAQhC0EoqXwAFxQbnBJWNtxbF-QqvLTSpUQEpwtJ123qdKk2AkSPD2pWhCc9rAzszsfIZcUEgo0u10nofUJAwYJ6AQgPSJDqqSKU6qyYzIEnemYUZYNyFkIawBgAuCUDDgHJjOlhyQdR_cYymWNPnrpMLSRa3zUrjAaF6uyqjBcR1PEKmpcNKtd1WH9Zc_JibNVwIvDHJG3x4fXyTSePz_NJuN5XHBB29hZ4EC1oplGubCASgsQ-cLxXKBgTOe5E0Lz1EmRSYncCVUImRfSgbTpgo_I3T532-UbXBRYt95WZuvLjfWfprGl-b-py5VZNh9GaVA81X3AzSHAN--7dmZThgKrytbYdMGwNNUsA85lL6V7aeGbEDy63zMUzI62WZuettnRNqBNT7v3XP3979fxg5d_AxqLezg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2449260337</pqid></control><display><type>article</type><title>A Designer Quest for the Achilles' Heel of Influenza</title><source>BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS</source><creator>Fajardo, J Eduardo ; Fiser, Andras</creator><creatorcontrib>Fajardo, J Eduardo ; Fiser, Andras</creatorcontrib><description>Monoclonal antibodies are attractive but, in certain applications, limited therapeutic modalities due to their large size and high specificity. In this issue of Structure, Sevy at al. describe a computationally designed cyclic peptide mimicking the CDRH3 loop of the C05 antibody against influenza showing the potential utility of designer biologics.</description><identifier>ISSN: 0969-2126</identifier><identifier>EISSN: 1878-4186</identifier><identifier>DOI: 10.1016/j.str.2020.09.004</identifier><identifier>PMID: 33027689</identifier><language>eng</language><publisher>United States</publisher><subject>Antibodies, Monoclonal ; Biophysical Phenomena ; Humans ; Influenza, Human - diagnosis ; Peptides, Cyclic</subject><ispartof>Structure (London), 2020-10, Vol.28 (10), p.1083-1084</ispartof><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c351t-fa030198169e7da0e89505bdf3b5e5229bbf55934f75677e3f58c57bc7f07a4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33027689$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fajardo, J Eduardo</creatorcontrib><creatorcontrib>Fiser, Andras</creatorcontrib><title>A Designer Quest for the Achilles' Heel of Influenza</title><title>Structure (London)</title><addtitle>Structure</addtitle><description>Monoclonal antibodies are attractive but, in certain applications, limited therapeutic modalities due to their large size and high specificity. In this issue of Structure, Sevy at al. describe a computationally designed cyclic peptide mimicking the CDRH3 loop of the C05 antibody against influenza showing the potential utility of designer biologics.</description><subject>Antibodies, Monoclonal</subject><subject>Biophysical Phenomena</subject><subject>Humans</subject><subject>Influenza, Human - diagnosis</subject><subject>Peptides, Cyclic</subject><issn>0969-2126</issn><issn>1878-4186</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpVkM1OwzAQhC0EoqXwAFxQbnBJWNtxbF-QqvLTSpUQEpwtJ123qdKk2AkSPD2pWhCc9rAzszsfIZcUEgo0u10nofUJAwYJ6AQgPSJDqqSKU6qyYzIEnemYUZYNyFkIawBgAuCUDDgHJjOlhyQdR_cYymWNPnrpMLSRa3zUrjAaF6uyqjBcR1PEKmpcNKtd1WH9Zc_JibNVwIvDHJG3x4fXyTSePz_NJuN5XHBB29hZ4EC1oplGubCASgsQ-cLxXKBgTOe5E0Lz1EmRSYncCVUImRfSgbTpgo_I3T532-UbXBRYt95WZuvLjfWfprGl-b-py5VZNh9GaVA81X3AzSHAN--7dmZThgKrytbYdMGwNNUsA85lL6V7aeGbEDy63zMUzI62WZuettnRNqBNT7v3XP3979fxg5d_AxqLezg</recordid><startdate>20201006</startdate><enddate>20201006</enddate><creator>Fajardo, J Eduardo</creator><creator>Fiser, Andras</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201006</creationdate><title>A Designer Quest for the Achilles' Heel of Influenza</title><author>Fajardo, J Eduardo ; Fiser, Andras</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-fa030198169e7da0e89505bdf3b5e5229bbf55934f75677e3f58c57bc7f07a4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antibodies, Monoclonal</topic><topic>Biophysical Phenomena</topic><topic>Humans</topic><topic>Influenza, Human - diagnosis</topic><topic>Peptides, Cyclic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fajardo, J Eduardo</creatorcontrib><creatorcontrib>Fiser, Andras</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Structure (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fajardo, J Eduardo</au><au>Fiser, Andras</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Designer Quest for the Achilles' Heel of Influenza</atitle><jtitle>Structure (London)</jtitle><addtitle>Structure</addtitle><date>2020-10-06</date><risdate>2020</risdate><volume>28</volume><issue>10</issue><spage>1083</spage><epage>1084</epage><pages>1083-1084</pages><issn>0969-2126</issn><eissn>1878-4186</eissn><abstract>Monoclonal antibodies are attractive but, in certain applications, limited therapeutic modalities due to their large size and high specificity. In this issue of Structure, Sevy at al. describe a computationally designed cyclic peptide mimicking the CDRH3 loop of the C05 antibody against influenza showing the potential utility of designer biologics.</abstract><cop>United States</cop><pmid>33027689</pmid><doi>10.1016/j.str.2020.09.004</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0969-2126
ispartof Structure (London), 2020-10, Vol.28 (10), p.1083-1084
issn 0969-2126
1878-4186
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8908349
source BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS
subjects Antibodies, Monoclonal
Biophysical Phenomena
Humans
Influenza, Human - diagnosis
Peptides, Cyclic
title A Designer Quest for the Achilles' Heel of Influenza
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T18%3A58%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Designer%20Quest%20for%20the%20Achilles'%20Heel%20of%20Influenza&rft.jtitle=Structure%20(London)&rft.au=Fajardo,%20J%20Eduardo&rft.date=2020-10-06&rft.volume=28&rft.issue=10&rft.spage=1083&rft.epage=1084&rft.pages=1083-1084&rft.issn=0969-2126&rft.eissn=1878-4186&rft_id=info:doi/10.1016/j.str.2020.09.004&rft_dat=%3Cproquest_pubme%3E2449260337%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c351t-fa030198169e7da0e89505bdf3b5e5229bbf55934f75677e3f58c57bc7f07a4d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2449260337&rft_id=info:pmid/33027689&rfr_iscdi=true