Efficacy of High-Ozonide Oil in Prevention of Cancer Relapses Mechanisms and Clinical Evidence

• Published in: Cancers 2022-02, Vol.14 (5), p.1174
• Main Authors: Izzotti, Alberto, Fracchia, Enzo, Rosano, Camillo, Comite, Antonio, Belgioia, Liliana, Sciacca, Salvatore, Khalid, Zumama, Congiu, Matteo, Colarossi, Cristina, Blanco, Giusi, Santoro, Antonio, Chiara, Massimo, Pulliero, Alessandra
• Format: Article
• Language: English
• Subjects: Adenocarcinoma; Angiogenesis; Antioxidants; Apoptosis; Aqueous solutions; Breast cancer; Calcium (intracellular); Calcium (mitochondrial); Cancer therapies; Chemoresistance; Chemotherapy; Colon; Colon cancer; Cytotoxicity; Glioblastoma; Hypoxia; Intracellular; Invasiveness; Lung cancer; MicroRNAs; Microscopy; Mitochondria; Molecular modelling; Neuroblastoma; Non-small cell lung carcinoma; Oral administration; Oxidation; Pancreas; Pancreatic cancer; Patients; Penicillin; Prostate cancer; Radiation therapy; Reactive oxygen species; Stem cells
• ISSN: 2072-6694; 2072-6694
• DOI: 10.3390/cancers14051174

Cancer tissue is characterized by low oxygen availability triggering neo angiogenesis and metastatisation. Accordingly, oxidation is a possible strategy for counteracting cancer progression and relapses. Previous studies used ozone gas, administered by invasive methods, both in experimental animals and clinical studies, transiently decreasing cancer growth. This study evaluated the effect of ozonized oils (administered either topically or orally) on cancer, exploring triggered molecular mechanisms. In vitro, in lung and glioblastoma cancer cells, ozonized oils having a high ozonide content suppressed cancer cell viability by triggering mitochondrial damage, intracellular calcium release, and apoptosis. In vivo, a total of 115 cancer patients (age 58 ± 14 years; 44 males, 71 females) were treated with ozonized oil as complementary therapy in addition to standard chemo/radio therapeutic regimens for up to 4 years. Cancer diagnoses were brain glioblastoma, pancreas adenocarcinoma, skin epithelioma, lung cancer (small and non-small cell lung cancer), colon adenocarcinoma, breast cancer, prostate adenocarcinoma. Survival rate was significantly improved in cancer patients receiving HOO as integrative therapy as compared with those receiving standard treatment only. These results indicate that ozonized oils at high ozonide may represent an innovation in complementary cancer therapy worthy of further clinical studies.