Cosmeceutical Therapy: Engaging the Repercussions of UVR Photoaging on the Skin's Circadian Rhythm

Sunlight is an important factor in regulating the central circadian rhythm, including the modulation of our sleep/wake cycles. Sunlight had also been discovered to have a prominent influence on our skin's circadian rhythm. Overexposure or prolonged exposure to the sun can cause skin photodamage...

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Published in:International journal of molecular sciences 2022-03, Vol.23 (5), p.2884
Main Authors: Mahendra, Camille Keisha, Ser, Hooi-Leng, Pusparajah, Priyia, Htar, Thet Thet, Chuah, Lay-Hong, Yap, Wei Hsum, Tang, Yin-Quan, Zengin, Gokhan, Tang, Siah Ying, Lee, Wai Leng, Liew, Kai Bin, Ming, Long Chiau, Goh, Bey Hing
Format: Article
Language:English
Subjects:
Apoptosis
Cell division
Circadian rhythm
Circadian Rhythm - physiology
Circadian rhythms
Collagen
Cosmeceuticals
Cosmeceuticals - metabolism
DNA damage
DNA repair
Homeostasis
Humans
Kinases
Pigmentation
Proteins
Review
Skin - metabolism
Skin Aging
Skin cancer
Skin Diseases - metabolism
Sleep and wakefulness
Sun
Sunburn & sun tanning
Sunlight
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Summary:Sunlight is an important factor in regulating the central circadian rhythm, including the modulation of our sleep/wake cycles. Sunlight had also been discovered to have a prominent influence on our skin's circadian rhythm. Overexposure or prolonged exposure to the sun can cause skin photodamage, such as the formation of irregular pigmentation, collagen degradation, DNA damage, and even skin cancer. Hence, this review will be looking into the detrimental effects of sunlight on our skin, not only at the aspect of photoaging but also at its impact on the skin's circadian rhythm. The growing market trend of natural-product-based cosmeceuticals as also caused us to question their potential to modulate the skin's circadian rhythm. Questions about how the skin's circadian rhythm could counteract photodamage and how best to maximize its biopotential will be discussed in this article. These discoveries regarding the skin's circadian rhythm have opened up a completely new level of understanding of our skin's molecular mechanism and may very well aid cosmeceutical companies, in the near future, to develop better products that not only suppress photoaging but remain effective and relevant throughout the day.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23052884