Influence of Baseline Diastolic Blood Pressure on the Effects of Intensive Systolic Blood Pressure Lowering on the Risk of Stroke

Guidelines recommend lowering systolic blood pressure below 130 mm Hg, irrespective of previous strokes. However, there is a concern that lowering systolic blood pressure in people with low baseline diastolic blood pressure might increase the risk of stroke. We conducted a secondary analysis of the...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2022-04, Vol.79 (4), p.785-793
Main Authors: Shihab, Saeed, Boucher, Robert E., Abraham, Nikita, Wei, Guo, Beddhu, Srinivasan
Format: Article
Language:English
Subjects:
Antihypertensive Agents - pharmacology
Blood Pressure - physiology
Humans
Hypertension - complications
Hypertension - drug therapy
Secondary Prevention - methods
Stroke - epidemiology
Stroke - etiology
Stroke - prevention & control
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Summary:Guidelines recommend lowering systolic blood pressure below 130 mm Hg, irrespective of previous strokes. However, there is a concern that lowering systolic blood pressure in people with low baseline diastolic blood pressure might increase the risk of stroke. We conducted a secondary analysis of the Secondary Prevention of Small Subcortical Strokes trial that randomly assigned participants with a history of subcortical strokes to an intensive (
ISSN:0194-911X
1524-4563
1524-4563
DOI:10.1161/HYPERTENSIONAHA.121.18172