Factors associated with initial tidal volume selection during neonatal volume-targeted ventilation in two NICUs: a retrospective cohort study

Objective To quantify initial tidal volume (VT) during neonatal volume-targeted ventilation (VTV) and to characterize the agreement of initial VT with the limited-evidence available. Study design We performed a multi-center retrospective observational cohort study in two Neonatal Intensive Care Unit...

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Bibliographic Details
Published in:Journal of perinatology 2022-06, Vol.42 (6), p.756-760
Main Authors: Knake, Lindsey A., Alrifai, Mhd Wael, McCoy, Allison B., Guthrie, Scott O., Wright, Adam, Lehmann, Christoph U., Hatch, L. Dupree
Format: Article
Language:English
Subjects:
692/308/174
692/699/1785
692/700/1720
Agreements
Babies
Birth weight
Cohort analysis
Hospitals
Humans
Infant
Infant, Newborn
Infants
Informatics
Intensive care
Intensive care units
Intensive Care Units, Neonatal
Lung
Medicine
Medicine & Public Health
Neonatal care
Neonates
Newborn babies
Pediatric Surgery
Pediatrics
Regression analysis
Respiration, Artificial
Retrospective Studies
Statistical analysis
Tidal Volume
Variables
Ventilation
Ventilators
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Summary:Objective To quantify initial tidal volume (VT) during neonatal volume-targeted ventilation (VTV) and to characterize the agreement of initial VT with the limited-evidence available. Study design We performed a multi-center retrospective observational cohort study in two Neonatal Intensive Care Units evaluating 313 infants who received VTV as the initial ventilation modality prior to postnatal day 14. We generated descriptive statistics and performed multivariable logistic regression analysis to determine factors associated with initial VT use that agreed with available literature. Results 154 (49%) infants received an initial VT of 5.0 mL/kg (median 5.0 mL/kg, IQR 5.0–5.1). 45 (14%) infants received an initial VT that was congruent with available literature. A birth weight of 700 –
ISSN:0743-8346
1476-5543
DOI:10.1038/s41372-022-01362-0