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Barley microgreen incorporation in diet-controlled diabetes and counteracted aflatoxicosis in rats
Increased environmental pollution and unhealthy lifestyle are blamed for escalated chronic diseases. Exposure to aflatoxins was recently suggested to have a role in the increased incidence of type 2 diabetes mellitus. Diet modification and consumption of different functional food are now gaining att...
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Published in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 2022-03, Vol.247 (5), p.385-394 |
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description | Increased environmental pollution and unhealthy lifestyle are blamed for escalated chronic diseases. Exposure to aflatoxins was recently suggested to have a role in the increased incidence of type 2 diabetes mellitus. Diet modification and consumption of different functional food are now gaining attention, especially in diabetes management. This study investigates the effect of a diet containing barley microgreen against diabetes induced by streptozotocin with or without aflatoxin administration in rats. Barley microgreen was rich in 3′-Benzyloxy-5,6,7,4′-tetramethoxyflavone (48.8% of total) followed by 5β,7βH,10α-Eudesm-11-en-1α-ol (18.46%). Streptozotocin injection and/or aflatoxin administration significantly elevated glucose level, decreased insulin level, decreased β-cell function, deteriorated liver and kidney function parameters, and induced oxidative stress in the liver. Histopathology revealed irregular small-sized islets and decreased area % of insulin-positive beta cells in the pancreas, hepatic degeneration, nephropathy, and neuropathy in diabetic and/or aflatoxin administered rats compared to control. Barley microgreen diet fed to diabetic rats with or without aflatoxin alleviated all evaluated parameters. Barley microgreen diet also ameliorated the toxic effect of aflatoxin. In conclusion, exposure to aflatoxin aggravated diabetes and its complication. The incorporation of barley microgreen in the diet was able to control type 2 diabetes mellitus and the improved outcomes observed with barley microgreen treatments involved or occurred in conjunction with improved biomarkers of oxidative stress. |
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Exposure to aflatoxins was recently suggested to have a role in the increased incidence of type 2 diabetes mellitus. Diet modification and consumption of different functional food are now gaining attention, especially in diabetes management. This study investigates the effect of a diet containing barley microgreen against diabetes induced by streptozotocin with or without aflatoxin administration in rats. Barley microgreen was rich in 3′-Benzyloxy-5,6,7,4′-tetramethoxyflavone (48.8% of total) followed by 5β,7βH,10α-Eudesm-11-en-1α-ol (18.46%). Streptozotocin injection and/or aflatoxin administration significantly elevated glucose level, decreased insulin level, decreased β-cell function, deteriorated liver and kidney function parameters, and induced oxidative stress in the liver. Histopathology revealed irregular small-sized islets and decreased area % of insulin-positive beta cells in the pancreas, hepatic degeneration, nephropathy, and neuropathy in diabetic and/or aflatoxin administered rats compared to control. Barley microgreen diet fed to diabetic rats with or without aflatoxin alleviated all evaluated parameters. Barley microgreen diet also ameliorated the toxic effect of aflatoxin. In conclusion, exposure to aflatoxin aggravated diabetes and its complication. 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Exposure to aflatoxins was recently suggested to have a role in the increased incidence of type 2 diabetes mellitus. Diet modification and consumption of different functional food are now gaining attention, especially in diabetes management. This study investigates the effect of a diet containing barley microgreen against diabetes induced by streptozotocin with or without aflatoxin administration in rats. Barley microgreen was rich in 3′-Benzyloxy-5,6,7,4′-tetramethoxyflavone (48.8% of total) followed by 5β,7βH,10α-Eudesm-11-en-1α-ol (18.46%). Streptozotocin injection and/or aflatoxin administration significantly elevated glucose level, decreased insulin level, decreased β-cell function, deteriorated liver and kidney function parameters, and induced oxidative stress in the liver. Histopathology revealed irregular small-sized islets and decreased area % of insulin-positive beta cells in the pancreas, hepatic degeneration, nephropathy, and neuropathy in diabetic and/or aflatoxin administered rats compared to control. Barley microgreen diet fed to diabetic rats with or without aflatoxin alleviated all evaluated parameters. Barley microgreen diet also ameliorated the toxic effect of aflatoxin. In conclusion, exposure to aflatoxin aggravated diabetes and its complication. The incorporation of barley microgreen in the diet was able to control type 2 diabetes mellitus and the improved outcomes observed with barley microgreen treatments involved or occurred in conjunction with improved biomarkers of oxidative stress.</description><subject>Aflatoxins - toxicity</subject><subject>Animals</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diet</subject><subject>Hordeum</subject><subject>Insulin</subject><subject>Original Research</subject><subject>Rats</subject><subject>Streptozocin</subject><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kN9KwzAUxoMobk4fwBvpC3Q2SdM0N4IO_8HAG70u6cnpzOiakXTi3t6UuaEIQiA5Od_3ncOPkEuaTSmV8poKLrjMGKM0E0oW4oiMh7-UF0od799RMCJnISyzjArJilMy4rlUheR0TOo77VvcJisL3i08YpfYDpxfO69764YqMRb7FFzXe9e2aGKta-wxJLozCbhN16PX0MeOblrdu08LLtgwWGNIOCcnjW4DXnzfE_L2cP86e0rnL4_Ps9t5Cjkv4wCFghuNoAVjohGF4UoCNyUgAMeCGSZySWvJlEQEled1QZsSFGNAFdN8Qm52uetNvUIDGBfWbbX2dqX9tnLaVr87nX2vFu6jKhVVPJ4JobuAiCIEj83BS7NqAF79AR49Vz-HHhx7wlEw3QmCXmC1dBvfRQj_JH4BccyMcQ</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Mohamed, Sara M</creator><creator>Abdel-Rahim, Emam A</creator><creator>Aly, Tahany AA</creator><creator>Naguib, AbdelMoneim M</creator><creator>Khattab, Marwa S</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8068-6094</orcidid></search><sort><creationdate>20220301</creationdate><title>Barley microgreen incorporation in diet-controlled diabetes and counteracted aflatoxicosis in rats</title><author>Mohamed, Sara M ; Abdel-Rahim, Emam A ; Aly, Tahany AA ; Naguib, AbdelMoneim M ; Khattab, Marwa S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-c9e53daeca5225f56d397c3d8cecc3e62d25471b7297eec944b61f8c922c192a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aflatoxins - toxicity</topic><topic>Animals</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diet</topic><topic>Hordeum</topic><topic>Insulin</topic><topic>Original Research</topic><topic>Rats</topic><topic>Streptozocin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohamed, Sara M</creatorcontrib><creatorcontrib>Abdel-Rahim, Emam A</creatorcontrib><creatorcontrib>Aly, Tahany AA</creatorcontrib><creatorcontrib>Naguib, AbdelMoneim M</creatorcontrib><creatorcontrib>Khattab, Marwa S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohamed, Sara M</au><au>Abdel-Rahim, Emam A</au><au>Aly, Tahany AA</au><au>Naguib, AbdelMoneim M</au><au>Khattab, Marwa S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Barley microgreen incorporation in diet-controlled diabetes and counteracted aflatoxicosis in rats</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Exp Biol Med (Maywood)</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>247</volume><issue>5</issue><spage>385</spage><epage>394</epage><pages>385-394</pages><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Increased environmental pollution and unhealthy lifestyle are blamed for escalated chronic diseases. 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Histopathology revealed irregular small-sized islets and decreased area % of insulin-positive beta cells in the pancreas, hepatic degeneration, nephropathy, and neuropathy in diabetic and/or aflatoxin administered rats compared to control. Barley microgreen diet fed to diabetic rats with or without aflatoxin alleviated all evaluated parameters. Barley microgreen diet also ameliorated the toxic effect of aflatoxin. In conclusion, exposure to aflatoxin aggravated diabetes and its complication. The incorporation of barley microgreen in the diet was able to control type 2 diabetes mellitus and the improved outcomes observed with barley microgreen treatments involved or occurred in conjunction with improved biomarkers of oxidative stress.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>34796731</pmid><doi>10.1177/15353702211059765</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-8068-6094</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Aflatoxins - toxicity Animals Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Type 2 - drug therapy Diet Hordeum Insulin Original Research Rats Streptozocin |
title | Barley microgreen incorporation in diet-controlled diabetes and counteracted aflatoxicosis in rats |
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