Effectiveness of an outbreak dose of mumps-containing vaccine in two First Nations communities in Northern Ontario, Canada

Between 18 Dec 2017 and 27 June 2018, a mumps outbreak occurred in two Canadian Indigenous communities. An outbreak dose of mumps-containing vaccine was offered as part of control measures. We conducted a cohort study and survival analysis to describe the outbreak and evaluate the outbreak dose, ext...

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Bibliographic Details
Published in:Human vaccines & immunotherapeutics 2022-12, Vol.18 (1), p.1870909-1870909
Main Authors: Rudnick, Wallis, Wilson, Sarah, Majerovich, Jo Ann, Haavaldsrud, Michelle, Gatali, Marene, Matsumoto, Cai-Lei, Deeks, Shelley
Format: Article
Language:English
Subjects:
Cohort Studies
Disease Outbreaks - prevention & control
Humans
immunization
Licensed Vaccines – Research Paper
Measles - prevention & control
Measles-Mumps-Rubella Vaccine
Mumps
Mumps - epidemiology
Mumps - prevention & control
Ontario - epidemiology
outbreak dose
Vaccination
vaccine Effectiveness
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Summary:Between 18 Dec 2017 and 27 June 2018, a mumps outbreak occurred in two Canadian Indigenous communities. An outbreak dose of mumps-containing vaccine was offered as part of control measures. We conducted a cohort study and survival analysis to describe the outbreak and evaluate the outbreak dose, extracting vaccination information on all community members (n = 3,135) from vaccination records. There were 70 mumps cases; 56% had received two pre-outbreak vaccine doses. Those who received a pre-outbreak dose more distantly had higher rates of mumps compared to those with more recent doses (adjusted hazard ratio = 3.4 (95%CI: 0.7-20.6) for receipt >20 years before vs. receipt ≤3 years). During the outbreak, 33% (1,010/3,080) of eligible individuals received an outbreak dose. The adjusted hazard ratio for no outbreak dose receipt was 2.7 (95%CI: 1.0-10.1). Our results suggest that an outbreak dose of mumps-containing vaccine may be an effective public health intervention, but further study is warranted.
ISSN:2164-5515
2164-554X
DOI:10.1080/21645515.2020.1870909