Significance of chemotherapy-free interval and tumor regression grade in patients with recurrent esophageal squamous cell carcinoma receiving chemotherapy with fluorouracil and platinum after esophagectomy following preoperative chemotherapy

Background In Japan, standard treatment for locally advanced esophageal squamous cell carcinoma (ESCC) includes preoperative chemotherapy with fluorouracil plus cisplatin followed by esophagectomy. However, its efficacy is unclear in patients with recurrent disease with 

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Bibliographic Details
Published in:Esophagus : official journal of the Japan Esophageal Society 2022-04, Vol.19 (2), p.240-249
Main Authors: Okunaka, Mashiro, Kotani, Daisuke, Demachi, Ken, Fujiwara, Hisashi, Sakashita, Shingo, Yoshino, Takayuki, Fujita, Takeo, Kojima, Takashi
Format: Article
Language:English
Subjects:
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cancer surgery
Chemotherapy
Cisplatin - therapeutic use
Clinical outcomes
Esophageal cancer
Esophageal Neoplasms - drug therapy
Esophageal Neoplasms - pathology
Esophageal Neoplasms - surgery
Esophageal Squamous Cell Carcinoma - drug therapy
Esophageal Squamous Cell Carcinoma - pathology
Esophageal Squamous Cell Carcinoma - surgery
Esophagectomy
Fluorouracil - therapeutic use
Gastroenterology
Humans
Immunotherapy
Medicine
Medicine & Public Health
Monoclonal antibodies
Neoplasm Recurrence, Local - pathology
Original
Original Article
Platinum - therapeutic use
Retrospective Studies
Squamous cell carcinoma
Surgical Oncology
Targeted cancer therapy
Thoracic Surgery
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Description
Summary:Background In Japan, standard treatment for locally advanced esophageal squamous cell carcinoma (ESCC) includes preoperative chemotherapy with fluorouracil plus cisplatin followed by esophagectomy. However, its efficacy is unclear in patients with recurrent disease with 
ISSN:1612-9059
1612-9067
DOI:10.1007/s10388-021-00885-3