Type A thymoma in a pet rabbit

A 4-y-old, spayed female, mixed-breed domesticated rabbit (Oryctolagus cuniculus domesticus) was presented because of progressive bilateral exophthalmos, with a large mediastinal mass in the cranial thorax. Palliative radiation therapy was elected, and 4 fractions of 5 Gy were delivered twice weekly...

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Bibliographic Details
Published in:Journal of veterinary diagnostic investigation 2022-03, Vol.34 (2), p.327-330
Main Authors: Robson, Halley R., Yanez, Ryan A., Magestro, Leanne M., French, Stephanie J., Kiupel, Matti
Format: Article
Language:English
Subjects:
Animals
Brief Reports
Female
Rabbits
Thymoma - diagnostic imaging
Thymoma - veterinary
Thymus Neoplasms - diagnostic imaging
Thymus Neoplasms - veterinary
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Summary:A 4-y-old, spayed female, mixed-breed domesticated rabbit (Oryctolagus cuniculus domesticus) was presented because of progressive bilateral exophthalmos, with a large mediastinal mass in the cranial thorax. Palliative radiation therapy was elected, and 4 fractions of 5 Gy were delivered twice weekly under general anesthesia using 3-dimensional conformal radiation therapy for a total dose of 20 Gy, guided by an on-board cone beam CT scan. Quality-of-life and respiratory rate improved before sudden death that followed an episode of dyspnea. The overall survival time following initial diagnosis was 93 d, with 68 d after the first dose of radiation. An autopsy was performed, and the mass was diagnosed as a type A thymoma. The diagnosis was confirmed with positive immunohistochemical labeling of the neoplastic cells for cytokeratin 5/6 and cytokeratin 7.
ISSN:1040-6387
1943-4936
DOI:10.1177/10406387221077086