STEP to blood pressure management of elderly hypertension: evidence from Asia

With a rapidly aging population, adequate blood pressure (BP) control is critical for hypertension management and prevention of cardiovascular events. Impressive cardiovascular benefits have been observed with intensive BP control (SBP target,

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Published in:Hypertension research 2022-04, Vol.45 (4), p.576-582
Main Authors: Zhang, Wei-Li, Cai, Jun
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Antihypertensive Agents - pharmacology
Blood Pressure
Blood Pressure Determination
Cardiovascular Diseases - epidemiology
China
Humans
Hypertension
Middle Aged
Multicenter Studies as Topic
Older people
Randomized Controlled Trials as Topic
Review
Stroke
White people
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cited_by cdi_FETCH-LOGICAL-c430t-e595458f890bc4fdede21768f63cf20d04af3307f72a9569e1cad08066c977b73
cites cdi_FETCH-LOGICAL-c430t-e595458f890bc4fdede21768f63cf20d04af3307f72a9569e1cad08066c977b73
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container_title Hypertension research
container_volume 45
creator Zhang, Wei-Li
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description With a rapidly aging population, adequate blood pressure (BP) control is critical for hypertension management and prevention of cardiovascular events. Impressive cardiovascular benefits have been observed with intensive BP control (SBP target,
doi_str_mv 10.1038/s41440-022-00875-7
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Impressive cardiovascular benefits have been observed with intensive BP control (SBP target, &lt;120 mmHg) in the SPRINT (Systolic Blood Pressure Intervention Trial) study, even in patients 75 years of age or older. A most recent meta-analysis including 51 randomized trials with over 350,000 participants from the BPLTTC (The Blood Pressure Lowering Treatment Trialists' Collaboration) showed that BP lowering is effective in older people for reducing major cardiovascular events. The STEP (Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients) study-a multicenter, randomized, controlled trial conducted in China, provided important evidence that intensive BP treatment (SBP target, 110 mmHg to &lt;130 mmHg) benefits older hypertensive patients (aged 60-80 years) and reduced the incidence of cardiovascular events than standard treatment (target 130 mmHg to &lt;150 mmHg). Because Asian people have a higher burden of hypertension and stroke than Caucasian people, intensive BP treatment has more advantages in reducing the risk of cardiovascular events including stroke in Asian hypertensive patients than in Caucasian people. Home BP monitoring is helpful to facilitate hypertension management for older patients. It should also be noted that clinical decision-making should be on a patient basis, such as fragility, diabetes, stroke, and other comorbidities, with tailored BP targets. 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subjects Aged
Aged, 80 and over
Antihypertensive Agents - pharmacology
Blood Pressure
Blood Pressure Determination
Cardiovascular Diseases - epidemiology
China
Humans
Hypertension
Middle Aged
Multicenter Studies as Topic
Older people
Randomized Controlled Trials as Topic
Review
Stroke
White people
title STEP to blood pressure management of elderly hypertension: evidence from Asia
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