Transient modifications of the olfactory bulb on MR follow-up of COVID-19 patients with related olfactory dysfunction

• Published in: Journal of neuroradiology 2022-06, Vol.49 (4), p.329-332
• Main Authors: Ammar, Amine, Distinguin, Lea, Chetrit, Anaelle, Safa, Dominique, Hans, Stephane, Carlier, Robert, Lechien, Jerome R., Edjlali, Myriam
• Format: Article
• Language: English
• Subjects: Anosmia; Anosmia - diagnostic imaging; Anosmia - etiology; Bioengineering; COVID-19; COVID-19 - complications; Follow-Up Studies; Humans; Imaging; Life Sciences; Magnetic resonance imaging; Magnetic Resonance Imaging - adverse effects; Olfaction disorders; Olfaction Disorders - diagnostic imaging; Olfaction Disorders - etiology; Olfactory Bulb - diagnostic imaging; Original; Prospective Studies; SARS-CoV-2; Smell
• ISSN: 0150-9861; 0150-9861
• DOI: 10.1016/j.neurad.2022.03.003

: Olfactory dysfunction (OD) has been reported with a high prevalence on mild to moderate COVID-19 patients. Previous reports suggest that volume and signal intensity of olfactory bulbs (OB) have been reported as abnormal on acute phase of COVID-19 anosmia, but a prospective MRI and clinical follow-up study of COVID-19 patients presenting with OD was missing, aiming at understanding the modification of OB during patients'follow-up. : A prospective multicenter study was conducted including 11 COVID-19 patients with OD. Patients underwent MRI and psychophysical olfactory assessments at baseline and 6-month post-COVID-19. T2 FLAIR-Signal intensity ratio (SIR) was measured between the average signal of the OB and the average signal of white matter. OB volumes and obstruction of olfactory clefts (OC) were evaluated at both evaluation times. : The psychophysical evaluations demonstrated a 6-month recovery in 10/11 patients (90.9%). The mean values of OB-SIR significantly decreased from baseline (1.66±0.24) to 6-month follow-up (1.35±0.27), reporting a mean variation of -17.82±15.20 % (p