Mesopic Disability Glare in Stage-Two Dysfunctional Lens Syndrome

• Published in: Ophthalmology and therapy 2022-04, Vol.11 (2), p.677-687
• Main Authors: Holgueras, Alfredo, Marcos, Manuel, Martínez-Plaza, Elena, López-Miguel, Alberto, Mansilla, Alberto, Maldonado, Miguel J.
• Format: Article
• Language: English
• Subjects: Internal Medicine; Medicine; Medicine & Public Health; Ophthalmology; Original Research
• ISSN: 2193-8245; 2193-6528
• DOI: 10.1007/s40123-022-00462-6

Introduction There is a lack of evidence about the exact deterioration of visual function associated with the age-related natural changes in the lens, particularly in intermediate (stage-2) dysfunctional lens syndrome (DLS). Standard photopic visual acuity and contrast sensitivity tests may not show the visual worsening in daily life activities, such as oncoming vehicle headlights at night. The purpose of this study was to analyze visual function under different conditions and glare sources in stage-2 DLS. Methods Forty patients over 49 years of age with initial bilateral lens opacification (Lens Opacities Classification System III [LOCS-III] scores up to 3), best-corrected visual acuity of 20/25 or better, and no ocular disease were evaluated. Binocular photopic and mesopic contrast sensitivity (CS) with/without halogen and xenon increasing glare sources were analyzed. Mesopic disability glare (MDG) was calculated as the difference between mesopic CS with/without the glare source. Results The median logarithmic CS (logCS) values were lower under mesopic conditions (1.05) than under photopic illumination (1.65; P