Goal discrimination in hippocampal nonplace cells when place information is ambiguous

SignificanceGoal-directed spatial navigation has been found to rely on hippocampal neurons that are spatially modulated. We show that "nonplace" cells without significant spatial modulation play a role in discriminating goals when environmental cues for goals are ambiguous. This nonplace c...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2022-03, Vol.119 (11), p.e2107337119-e2107337119
Main Authors: Zhang, Lu, Prince, Stephanie M, Paulson, Abigail L, Singer, Annabelle C
Format: Article
Language:English
Subjects:
Action Potentials
Alzheimer's disease
Animals
Biological Sciences
Brain Waves
Cell differentiation
Cues
Discrimination
Discrimination Learning
Environment
Hippocampus
Hippocampus - cytology
Hippocampus - physiology
Mice
Neural coding
Neurodegenerative diseases
Phase modulation
Pyramidal cells
Pyramidal Cells - physiology
Spatial data
Spatial Navigation
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Summary:SignificanceGoal-directed spatial navigation has been found to rely on hippocampal neurons that are spatially modulated. We show that "nonplace" cells without significant spatial modulation play a role in discriminating goals when environmental cues for goals are ambiguous. This nonplace cell activity is performance-dependent and is modulated by gamma oscillations. Finally, nonplace cell goal discrimination coding fails in a mouse model of Alzheimer's disease (AD). Together, these results show that nonplace cell firing can signal unique task-relevant information when spatial information is ambiguous; these signals depend on performance and are absent in a mouse model of AD.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.2107337119