Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis

SignificanceThe study provided a long-sought molecular mechanism that could explain the link between fatty acid metabolism and cancer metastasis. Further understanding may lead to new strategies to inhibit cancer metastasis. The chemical proteomic approach developed here will be useful for discoveri...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2022-03, Vol.119 (11), p.e2117013119-e2117013119
Main Authors: Zhang, Shuai, Nelson, Ornella D, Price, Ian R, Zhu, Chengliang, Lu, Xuan, Fernandez, Irma R, Weiss, Robert S, Lin, Hening
Format: Article
Language:English
Subjects:
Acyl Coenzyme A - metabolism
Animal models
Biological Sciences
Breast cancer
Breast Neoplasms
Cancer
Cell migration
Clathrin
Coenzyme A
Endocytosis
Fatty acids
Female
High fat diet
Humans
Intermediates
Metabolism
Metabolites
Metastases
Metastasis
Molecular chains
Neoplasm Metastasis
Neoplasms - etiology
Neoplasms - metabolism
Neoplasms - pathology
NM23 Nucleoside Diphosphate Kinases - antagonists & inhibitors
Oxidation
Protein Binding
Protein turnover
Proteins
Proteome
Proteomics
Proteomics - methods
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Description
Summary:SignificanceThe study provided a long-sought molecular mechanism that could explain the link between fatty acid metabolism and cancer metastasis. Further understanding may lead to new strategies to inhibit cancer metastasis. The chemical proteomic approach developed here will be useful for discovering other regulatory mechanisms of protein function by small molecule metabolites.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.2117013119