Effects of vitamin D with or without calcium on pathological ossification: A retrospective clinical study

Vitamin D protects against the development and severity of several rheumatic diseases. However, the effect of vitamin D on the pathological ossification associated with rheumatic diseases remains unknown. The present retrospective study analyzed the clinical outcomes of vitamin D without calcium com...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2022-04, Vol.23 (4), Article 285
Main Authors: Liang, Libin, Tong, Tong, Qin, Luyang, Xie, Jing, Xu, Yanping, Qin, Yuguo, Zhang, Lansen, Liu, Dehui, Niu, Xiaoyun, Tong, Xinglong
Format: Article
Language:English
Subjects:
Age
Alfacalcidol
Arthritis
Bones
Calcifediol
Care and treatment
Cartilage
Clinical outcomes
Dietary supplements
Health aspects
Ligaments
Metabolism
Mineralization
Ossification
Osteoarthritis
Phosphorus
Rheumatic diseases
Rheumatoid arthritis
Spondyloarthropathies
Vitamin D
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Summary:Vitamin D protects against the development and severity of several rheumatic diseases. However, the effect of vitamin D on the pathological ossification associated with rheumatic diseases remains unknown. The present retrospective study analyzed the clinical outcomes of vitamin D without calcium compared with vitamin D with calcium on pathological ossification in joints and ligaments. Data were collected from patients who were diagnosed with osteoarthritis, rheumatoid arthritis or spondylarthritis, and the presence of pathological ossification in joints or ligaments was confirmed by X-ray, computed tomography or magnetic resonance imaging examination. A total of 2,965 patients aged 18-75 years old were included, among who, 1,725 were included in the vitamin D alone group and 1,240 in the vitamin D with calcium group. Vitamin D was administered intramuscularly (300,000 IU) once every 7-10 days, 4-6 times in total. Patients who ingested an oral calcium supplement (1,000 mg/day; [greater than or equal to] 5 days/week) were considered the vitamin D with calcium group. The clinical outcome was evaluated based on the imaging changes of pathological ossification, which were classified as alleviation, aggravation and unchanged. The bone mineral density (BMD) was determined, and the calcium concentration in the serum and urine was measured. The results revealed that vitamin D alone alleviated pathological ossification, while vitamin D combined with calcium aggravated pathological ossification in the majority of patients (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2022.11214