Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review

The coronavirus disease 2019 (COVID-19) has overwhelming healthcare systems globally. To date, a myriad of therapeutic regimens has been employed in an attempt to curb the ramifications of a severe COVID-19 infection. Amidst the ongoing pandemic, the advent and efficacious uptake of COVID-19 vaccina...

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Published in:Biomedicine & pharmacotherapy 2022-05, Vol.149, p.112843-112843, Article 112843
Main Authors: Almas, Talal, Rehman, Sarah, Mansour, Eyad, Khedro, Tarek, Alansari, Ali, Malik, Jahanzeb, Alshareef, Norah, Nagarajan, Vikneswaran Raj, Al-Awaid, Abdulla Hussain, Alsufyani, Reema, Alsufyani, Majid, Rifai, Ali, Alzahrani, Ahlam, Nagarajan, Dhineswaran Raj, Abdullatif, Tala, Gunasaegaram, Varman, Alzadjali, Enaam, Subramanian, Arthi, Rahman, Abida, Sattar, Yasar, Galo, Jason, Virk, Hafeez Ul Hassan, Alraies, M. Chadi
Format: Article
Language:English
Subjects:
Coronavirus 2019 (COVID-19)
COVID-19 - epidemiology
COVID-19 - prevention & control
COVID-19 mRNA vaccine
COVID-19 myocarditis
COVID-19 perimyocarditis
COVID-19 Vaccines - adverse effects
Humans
Review
RNA, Messenger - genetics
SARS-CoV-2
Takotsubo syndrome
Vaccination - adverse effects
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container_title Biomedicine & pharmacotherapy
container_volume 149
creator Almas, Talal
Rehman, Sarah
Mansour, Eyad
Khedro, Tarek
Alansari, Ali
Malik, Jahanzeb
Alshareef, Norah
Nagarajan, Vikneswaran Raj
Al-Awaid, Abdulla Hussain
Alsufyani, Reema
Alsufyani, Majid
Rifai, Ali
Alzahrani, Ahlam
Nagarajan, Dhineswaran Raj
Abdullatif, Tala
Gunasaegaram, Varman
Alzadjali, Enaam
Subramanian, Arthi
Rahman, Abida
Sattar, Yasar
Galo, Jason
Virk, Hafeez Ul Hassan
Alraies, M. Chadi
description The coronavirus disease 2019 (COVID-19) has overwhelming healthcare systems globally. To date, a myriad of therapeutic regimens has been employed in an attempt to curb the ramifications of a severe COVID-19 infection. Amidst the ongoing pandemic, the advent and efficacious uptake of COVID-19 vaccination has significantly reduced disease-related hospitalizations and mortality. Nevertheless, many side-effects are being reported after COVID-19 vaccinations and myocarditis is the most commonly reported sequelae post vaccination. Majority of these diseases are associated with COVID-19 mRNA vaccines. Various studies have established a temporal relationship between these complications, yet the causality and the underlying pathogenesis remain hypothetical. In this review, we aim to critically appraise the available literature regarding the cardiovascular side effects of the various mRNA vaccines and the associated pathophysiology. [Display omitted]
doi_str_mv 10.1016/j.biopha.2022.112843
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subjects Coronavirus 2019 (COVID-19)
COVID-19 - epidemiology
COVID-19 - prevention & control
COVID-19 mRNA vaccine
COVID-19 myocarditis
COVID-19 perimyocarditis
COVID-19 Vaccines - adverse effects
Humans
Review
RNA, Messenger - genetics
SARS-CoV-2
Takotsubo syndrome
Vaccination - adverse effects
title Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review
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