The non-pharmaceutical interventions may affect the advantage in transmission of mutated variants during epidemics: A conceptual model for COVID-19

•Genetic mutations in SARS-CoV-2 emerge, and some of them appears more contagious than historical strains.•The transmission advantage of genetic variants is an innate biological feature that is difficult to be altered by artificial factors.•We demonstrate that NPIs could lead to changes in transmiss...

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Bibliographic Details
Published in:Journal of theoretical biology 2022-06, Vol.542, p.111105-111105, Article 111105
Main Authors: Zhao, Shi, Wang, Kai, Chong, Marc K.C., Musa, Salihu S., He, Mu, Han, Lefei, He, Daihai, Wang, Maggie H.
Format: Article
Language:English
Subjects:
COVID-19
COVID-19 - epidemiology
Epidemics
Humans
Mathematical modelling
Models, Theoretical
Non-pharmaceutical intervention
Pandemics
Reproduction number
SARS-CoV-2 - genetics
Transmission advantage
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Summary:•Genetic mutations in SARS-CoV-2 emerge, and some of them appears more contagious than historical strains.•The transmission advantage of genetic variants is an innate biological feature that is difficult to be altered by artificial factors.•We demonstrate that NPIs could lead to changes in transmission advantage.•Our findings highlight the important roles of NPIs not only in controlling epidemics but also in slowing the growth of variants. As the COVID-19 pandemic continues, genetic mutations in SARS-CoV-2 emerge, and some of them are found more contagious than the previously identified strains, acting as the major mechanism for many large-scale epidemics. The transmission advantage of mutated variants is widely believed as an innate biological feature that is difficult to be altered by artificial factors. In this study, we explore how non-pharmaceutical interventions (NPI) may affect transmission advantage. A two-strain compartmental epidemic model is proposed and simulated to investigate the biological mechanism of the relationships among different NPIs, the changes in transmissibility of each strain and transmission advantage. Although the NPIs are effective in flattening the epidemic curve, we demonstrate that NPIs probably lead to a decline in transmission advantage, which is likely to occur if the NPIs become intensive. Our findings uncover the mechanistic relationship between NPIs and transmission advantage dynamically, and highlight the important role of NPIs not only in controlling the intensity of epidemics but also in slowing or even containing the growth of the proportion of variants.
ISSN:0022-5193
1095-8541
DOI:10.1016/j.jtbi.2022.111105