Relationship of citrulline and tissue transglutaminase antibody with duodenal histopathology among children with celiac disease

Non-invasive biomarkers, for the diagnosis of celiac disease, can reduce the need for biopsy, particularly in pediatric patients. The aim of this study was to investigate the levels tissue transglutaminase antibody (tTG) and plasma citrulline and its correlation with intestinal biopsy. In this cross...

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Bibliographic Details
Published in:Annals of medicine and surgery 2022-04, Vol.76, p.103489-103489, Article 103489
Main Authors: Rahmani, Parisa, Heidari, Ghobad, Farahmand, Fatemeh, Moradzadeh, Alireza
Format: Article
Language:English
Subjects:
Antibody
Celiac disease
Citrulline
Cross-sectional Study
Pediatric
Plasma
Tissue transglutaminase antibody (tTG)
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Summary:Non-invasive biomarkers, for the diagnosis of celiac disease, can reduce the need for biopsy, particularly in pediatric patients. The aim of this study was to investigate the levels tissue transglutaminase antibody (tTG) and plasma citrulline and its correlation with intestinal biopsy. In this cross-sectional descriptive study, Pediatric patients with celiac disease referred to (XXX)were included. The patients underwent tTG antibody test along with plasma citrulline measurements using HPLC ((high performance liquid chromatography). Biopsy was performed in all the patients and clinical and demographic findings were recorded in a patient form. The data were statistically analyzed using SPSSv22. Of 118 patients with celiac disease, the mean level of citrulline in patients was 17.48 ± 6.92 and the mean tTG titer was 183.17 ± 41.25. The two variables were inversely correlated with each other, p 
ISSN:2049-0801
2049-0801
DOI:10.1016/j.amsu.2022.103489