In vitro activities of polycationic peptides alone and in combination with clinically used antimicrobial agents against Rhodococcus equi

The in vitro activities of magainin II, nisin, and ranalexin alone and in combination with other antimicrobial agents against six clinical isolates of Rhodococcus equi were investigated by MIC and time-kill studies. All isolates were more susceptible to nisin. A positive interaction was observed whe...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 1999-08, Vol.43 (8), p.2093-2096
Main Authors: GIACOMETTI, A, CIRIONI, O, ANCARANI, F, DEL PRETE, M. S, FORTUNA, M, SCALISE, G
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimicrobial Cationic Peptides
Biological and medical sciences
Drug Synergism
Humans
Magainins
Medical sciences
Microbial Sensitivity Tests
Nisin - pharmacology
Peptides - pharmacology
Peptides, Cyclic - pharmacology
Pharmacology. Drug treatments
Rhodococcus equi
Rhodococcus equi - drug effects
Rhodococcus equi - isolation & purification
Susceptibility
Xenopus Proteins
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Summary:The in vitro activities of magainin II, nisin, and ranalexin alone and in combination with other antimicrobial agents against six clinical isolates of Rhodococcus equi were investigated by MIC and time-kill studies. All isolates were more susceptible to nisin. A positive interaction was observed when the peptides were combined with ampicillin, ceftriaxone, rifabutin, rifampin, azithromycin, clarithromycin, and vancomycin.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.43.8.2093