Physical Fitness and Cardiovascular Risk Factors in Novel Diabetes Subgroups

Physical inactivity promotes insulin resistance and increases the risk of diabetes and cardiovascular disease. Recently introduced clustering based on simple clinical measures identified diabetes subgroups (clusters) with different risks of diabetes-related comorbidities and complications. This stud...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2022-03, Vol.107 (4), p.1127-1139
Main Authors: Saatmann, Nina, Zaharia, Oana-Patricia, Strassburger, Klaus, Pesta, Dominik Hans, Burkart, Volker, Szendroedi, Julia, Gerdes, Norbert, Kelm, Malte, Roden, Michael
Format: Article
Language:English
Subjects:
Cardiovascular Diseases - complications
Cardiovascular Diseases - etiology
Clinical
Comorbidity
Coronary heart disease
Dextrose
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - epidemiology
Diabetes therapy
Endothelium
Exercise
Glucose
Heart Disease Risk Factors
Humans
Insulin
Insulin Resistance
Longitudinal Studies
Nitrates
Physical Fitness
Prospective Studies
Risk Factors
Type 2 diabetes
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Summary:Physical inactivity promotes insulin resistance and increases the risk of diabetes and cardiovascular disease. Recently introduced clustering based on simple clinical measures identified diabetes subgroups (clusters) with different risks of diabetes-related comorbidities and complications. This study aims to determine differences in physical fitness and cardiovascular risk between diabetes subgroups and a glucose-tolerant control group (CON). We hypothesized that the severe insulin-resistant diabetes (SIRD) subgroup would be associated with lower physical fitness and increased cardiovascular risk. The physical fitness and cardiovascular risk of 746 participants with recent-onset diabetes (diabetes duration of
ISSN:0021-972X
1945-7197
DOI:10.1210/clinem/dgab810