The In Vitro Cytotoxicity of Eremothecium oil and Its Components-Aromatic and Acyclic Monoterpene Alcohols

The microscopic fungi and are known for their ability to synthetize essential oil, which has a composition similar to that of rose oil. The development of oil technology enables the production of rose-scented products, which are demanded by pharmaceutical, food, and perfumery industries. This study...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-03, Vol.23 (6), p.3364
Main Authors: Semenova, Elena, Presniakova, Victoria, Kozlovskaya, Vera, Markelova, Natalia, Gusev, Alexey, Linert, Wolfgang, Kurakov, Alexander, Shpichka, Anastasia
Format: Article
Language:English
Subjects:
Acyclic Monoterpenes
Alcohol
Alcohols
Animals
Antimicrobial agents
Bone marrow
Cell culture
Chemical composition
Chromatography
Composition
Cytotoxicity
Eremothecium
Essential oils
Food industry
Mesenchyme
Mice
Monoterpenes - analysis
Oils & fats
Oils, Volatile - analysis
Oils, Volatile - pharmacology
Rose oil
Stromal cells
Toxicity
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Summary:The microscopic fungi and are known for their ability to synthetize essential oil, which has a composition similar to that of rose oil. The development of oil technology enables the production of rose-scented products, which are demanded by pharmaceutical, food, and perfumery industries. This study focuses on assessing the in vitro cytotoxicity of oil, in comparison with that of rose oil, using a combination of methods and two cell types (3T3 mouse fibroblast cell line and bone-marrow-derived mesenchymal stromal cells (BM-MSCs)). The oil samples possessed cytotoxic effects that varied among strains and batches. The revealed cytotoxicity level may be used to tailor the qualitative and quantitative composition of oil to achieve a particular quality in its end products. These results require further analysis using other cell types and assays based on measuring other cell functions.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23063364