Sex-Specific Mortality from Asbestos-Related Diseases, Lung and Ovarian Cancer in Municipalities with High Asbestos Consumption, Brazil, 2000-2017

• Published in: International journal of environmental research and public health 2022-03, Vol.19 (6), p.3656
• Main Authors: Saito, Cézar Akiyoshi, Bussacos, Marco Antonio, Salvi, Leonardo, Mensi, Carolina, Consonni, Dario, Fernandes, Fernando Timoteo, Campos, Felipe, Cavalcante, Franciana, Algranti, Eduardo
• Format: Article
• Language: English
• Subjects: Adult; Asbestos; Asbestos - toxicity; Asbestosis; Brazil - epidemiology; Carcinoma, Ovarian Epithelial; Cement; Cities; Codes; Comorbidity; Disease; Ecological effects; Ecological studies; Fatalities; Female; Hospitals; Humans; Information systems; Italy; Latency; Lung; Lung cancer; Lung diseases; Lung Neoplasms; Male; Mesothelioma; Morphology; Mortality; Municipalities; Occupational Exposure; Ovarian cancer; Ovarian Neoplasms; Plaques; Population; Statistical analysis; Tumors; Womens health
• ISSN: 1660-4601; 1661-7827; 1660-4601
• DOI: 10.3390/ijerph19063656

The aim of this study is to compare the mortality rates for typical asbestos-related diseases (ARD-T: mesothelioma, asbestosis, and pleural plaques) and for lung and ovarian cancer in Brazilian municipalities where asbestos mines and asbestos-cement plants had been operating (areas with high asbestos consumption, H-ASB) compared with in other municipalities. The death records for adults aged 30+ years were retrieved from multiple health information systems. In the 2000-2017 time period, age-standardized mortality rates (standard: Brazil 2010) and standardized rate ratios (SRR; H-ASB vs. others) were estimated. The SRRs for ARD-T were 2.56 for men (257 deaths in H-ASB municipalities) and 1.19 for women (136 deaths). For lung cancer, the SRRs were 1.33 for men (32,604 deaths) and 1.19 for women (20,735 deaths). The SRR for ovarian cancer was 1.34 (8446 deaths). Except for ARD-T and lung cancer in women, the SRRs were higher in municipalities that began using asbestos before 1970 than in municipalities that began utilizing asbestos from 1970 onwards. In conclusion, the mortality rates for ARD-T, and lung and ovarian cancer in municipalities with a history of asbestos mining and asbestos-cement production exceed those of the whole country. Caution is needed when interpreting the results of this ecological study. Analytical studies are necessary to document the impact of asbestos exposure on health, particularly in the future given the long latency of asbestos-related cancers.