Downregulation of ATP binding cassette subfamily a member 10 acts as a prognostic factor associated with immune infiltration in breast cancer

The human ATP binding cassette (ABC) family of transporter proteins plays an important role in the maintenance of homeostasis . The aim of this study is to evaluate the potential diagnostic, prognostic, and therapeutic value of the ABCA10 gene in BRCA. We found that ABCA10 expression was downregulat...

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Published in:Aging (Albany, NY.) NY.), 2022-03, Vol.14 (5), p.2252-2267
Main Authors: Chu, Pei-Yi, Tzeng, Yen-Dun Tony, Tsui, Kuan-Hao, Chu, Ching-Yu, Li, Chia-Jung
Format: Article
Language:English
Subjects:
Adenosine Triphosphate
Biomarkers, Tumor - genetics
Breast Neoplasms - pathology
Databases, Genetic
DNA Copy Number Variations
Down-Regulation
Female
Gene Expression Regulation, Neoplastic
Humans
Prognosis
Research Paper
Tumor Microenvironment - genetics
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Summary:The human ATP binding cassette (ABC) family of transporter proteins plays an important role in the maintenance of homeostasis . The aim of this study is to evaluate the potential diagnostic, prognostic, and therapeutic value of the ABCA10 gene in BRCA. We found that ABCA10 expression was downregulated in different subgroups of breast cancer and strongly correlated with pathological stage in BRCA patients. Low expression of ABCA10 was associated with BRCA patients showing shorter overall survival (OS). ABCA10 expression may be regulated by promoter methylation, copy number variation (CNV) and kinase, and is associated with immune infiltration. Our study also demonstrated the potential role of ABCA10 modifications in tumor microenvironment (TME) cellular infiltration. Nevertheless, the regulatory mechanism remains unknown and immunotherapy is marginal in BRCA. We demonstrate the expression of different ABCA10 modulators in breast cancer associated with genetic variants, deletions, tumor mutation burden (TMB) and TME. Mutations in ABCA10 are positively associated with different immune cells in six different immune databases and play an important role in immune cell infiltration in breast cancer. Overall, this study provides evidence that ABCA10 could become the potential targets for precision treatment and new biomarkers in the prognosis of breast cancer.
ISSN:1945-4589
1945-4589
DOI:10.18632/aging.203933