Long Term Impact of Epicardial Left Atrial Appendage Ligation on Systemic Hemostasis: LAA HOMEOSTASIS-2

Recent data suggest that epicardial left atrial appendage closure (LAAC) is associated with several short-term neurohormonal effects. However, the long-term effects are currently unknown. To investigate the effects of percutaneous epicardial left atial appendage (LAA) exclusion using LARIAT on neuro...

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Published in:Journal of clinical medicine 2022-03, Vol.11 (6), p.1495
Main Authors: Bartus, Krzysztof, Kanuri, Sri Harsha, Litwinowicz, Radoslaw, Ali Elbey, Mehmet, Natorska, Joanna, Zabczyk, Michal, Bartus, Magdalena, Kapelak, Boguslaw, Gopinnathannair, Rakesh, Garg, Jalaj, Turagam, Mohit K, Malecki, Maciej T, Lee, Randall J, Lakkireddy, Dhanunjaya
Format: Article
Language:English
Subjects:
Blood clots
Blood pressure
Cardiovascular disease
Clinical medicine
Diabetes
Electrolytes
Heart failure
Hypertension
Patients
Peptides
Potassium
Sodium
Statistical analysis
Stroke
Transient ischemic attack
Ultrasonic imaging
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Summary:Recent data suggest that epicardial left atrial appendage closure (LAAC) is associated with several short-term neurohormonal effects. However, the long-term effects are currently unknown. To investigate the effects of percutaneous epicardial left atial appendage (LAA) exclusion using LARIAT on neurohormonal profiles at long-term follow-up. In a prospective single centre study, 60 patients with long-standing, persistent atrial fibrillation (AF) LARIAT were treated. The major hormones of the adrenergic system, renin-angiotensin-aldosterone system (RAAS), and natriuretic peptides were assessed before the intervention and at regular intervals during the following two years. In patients with epicardial LAAC, atrial natriuretic peptide (ANP) levels were significantly increased from baseline at 24 h and decreased at 7 days, 1 month, and 3 months, while remaining unchanged at 12 and 24 months. Noradrenaline levels were significantly lower at 24 h, 7 days, 1 month, 6 months, 12 months, and 24 months, while epinephrine levels decreased significantly at 1 month, 6 months, 12 months, and 24 months. Plasma renin activity significantly decreased at 7 days, 1 month, 6 months, 12 months, and 24 months, while aldosterone levels significantly decreased at 6 months, 12 months, and 24 months. Endothelin-1 and vasopressin showed a significant increase and decrease, respectively, at 24 h, 7 days, 1 month, 6 months, 12 months, and 24 months. There was also a significant decrease in systolic and diastolic blood pressure at 3 months, 6 months, 1 year, and 2 years after the intervention. Epicardial LAAC in AF patients is associated with persistent neurohormonal changes favouring blood pressure reduction.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11061495